Benzaldehyde dehydrogenase (NAD+)

benzaldehyde dehydrogenase (NAD+)
Identifiers
EC number	1.2.1.28
CAS number	37250-93-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a benzaldehyde dehydrogenase (NAD+) (EC 1.2.1.28) is an enzyme that catalyzes the chemical reaction

benzaldehyde + NAD⁺ + H₂O $\rightleftharpoons$ benzoate + NADH + 2 H⁺

The 3 substrates of this enzyme are benzaldehyde, NAD⁺, and H₂O, whereas its 3 products are benzoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is benzaldehyde:NAD+ oxidoreductase. Other names in common use include benzaldehyde (NAD+) dehydrogenase, and benzaldehyde dehydrogenase (NAD+). This enzyme participates in benzoate degradation via hydroxylation and toluene and xylene degradation.

References

• GUNSALUS CF, STANIER RY, GUNSALUS IC (1953). "THE ENZYMATIC CONVERSION OF MANDELIC ACID TO BENZOIC ACID III. : Fractionation and Properties of the Soluble Enzymes". J. Bacteriol. 66 (5): 548–53. PMC 317432. PMID 13108854.