Benzthiazide

Benzthiazide

Systematic (IUPAC) name
6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)- 4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
Legal status	℞ (Prescription only)
Pharmacokinetic data
Bioavailability	60 to 70%
Protein binding	30%
Biological half-life	5 to 15 hours
Excretion	Renal
Identifiers
CAS Number	91-33-8
ATC code	none
PubChem	CID 2343
IUPHAR/BPS	7125
DrugBank	DB00562
ChemSpider	2253
UNII	1TD8J48L61
KEGG	D00651
ChEBI	CHEBI:3047
ChEMBL	CHEMBL1201039
Chemical data
Formula	C15H14ClN3O4S3
Molar mass	431.94 g/mol
SMILES O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)/N=C(\N2)CSCc3ccccc3)N
InChI InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21) Key:NDTSRXAMMQDVSW-UHFFFAOYSA-N
(what is this?)  (verify)

Benzthiazide (BAN/INN, also known as benzothiazide; trade names Aquatag, Dihydrex, Diucen, Edemax, Exna, Foven and others^[1]) is a thiazide diuretic used in the treatment of high blood pressure and edema. It is no longer available in the United States.

In the United Kingdom, it was also sold in combination with the potassium-sparing diuretic triamterene under the trade name Dytide.^[2] The same combination is still available in Switzerland as Dyrenium compositum.^[3]

References

1. David J. Triggle; C. R. Ganellin; F. MacDonald (1996). Dictionary of Pharmacological Agents 1. Boca Raton: Chapman & Hall/CRC. p. 246. ISBN 0-412-46630-9. Retrieved on August 29, 2008 through Google Book Search.
2. "Triamterene and Benzthiazide". PatientUK. 2005. Retrieved 2008-08-29.
3. "Dyrenium compositum". Doetsch Grether. n.d. Archived from the original on February 11, 2007. Retrieved 2008-08-29.