Bergenia ligulata

Bergenia ligulata
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
(unranked): Core eudicots
Order: Saxifragales
Family: Saxifragaceae
Genus: Bergenia
Species: B. ligulata
Binomial name
Bergenia ligulata
(Wall.) Engl.

Bergenia ligulata (Paashaanbhed, Prashanbheda, and other spellings in Ayurveda traditional Indian medicine) is a plant belonging to the family Saxifragaceae and the genus Bergenia. The plant is mostly found in temperate Himalayas from Kashmir to Bhutan and in Khasia hills at 15,00 meter altitude.

Chemical constituents

B. ligulata contains A phenolic compound bergenin,[1][2][3] and afzelechin, a type of flavan-3-ol[4] and bergenin.[5]

Pharmacology

Alcoholic extract of the plant has exhibited significant anti-inflammatory, analgesic and diuretic properties.[6] Purified fraction of the drug has shown potent antibacterial activity.[7] Bergenia ligulata is a widely used plant in South Asia, mainly India and Pakistan, as a traditional medicine for treatment of urolithiasis or kidney stones. Data indicate antiurolithic activity in Bergenia ligulata, mediated possibly through CaC2O4 crystal inhibition, diuretic, hypermagneseuric and antioxidant effects, rationalizing its medicinal use for the treatment of kidney stones.[8] Maximum inhibition of the crystal growth of calcium oxalate monohydrate, a mineral in most kidney stones, was observed primarily with aqueous extracts of Bergenia ligulata followed by Tribulus terrestris, in a test tube study.[9]

This plant is sometimes treated as a form of Bergenia ciliata.

References

  1. ↑ Umashankar D.C., Chawla A.S., Deepak M., Singh D., and Handa S.S., Phytochemical AnaLysis 1999; 10, 44
  2. ↑ Bahl C.P., Murari R., Parthasarathy M.R., and Seshadri T.R., Indian J. Chem. 1974; 12, 1038
  3. ↑ Jain M.K., and Gupta R., J. Indian Chem. Soc. 1962; 39, 559
  4. ↑ High pressure liquid chromatographic determination of bergenin and (+) -afzelechin from different parts of Paashaanbhed (Bergenia ligulata yeo). Umashankar D. Chandra Reddy, Amrik S. Chawla, Mundkinajeddu Deepak, Deepa Singh , Sukhdev S. Handa, 1997
  5. ↑ Simultaneous quantification of bergenin, catechin, and gallic acid from Bergenia ciliata and Bergenia ligulata by using thin-layer chromatography. Dhalwal K.; Shinde V.M.; Biradar Y.S.; Mahadik K.R.; 2008
  6. ↑ Gehlot N.K., Sharma V.N., and Vyas D.S., Indian J Pharmacol. 8, 92(1976).
  7. ↑ Pandya K.K., Patel R.B., and Chakravarty B.K., Indian Drugs 27, 415(1990).
  8. ↑ Antiurolithic effect of Bergenia ligulata rhizome: an explanation of the underlying mechanisms. J Ethnopharmacol. 2009 Feb 25;122(1):106-16. Epub 2008 Dec 11.
  9. ↑ Joshi V.S. et al. Herbal extracts of Tribulus terrestris and Bergenia ligulata inhibit growth of calcium oxalate monohydrate crystals in vitro. Journal of Crystal Growth, Volume 275, Issues 1–2, 15 February 2005, Pages e1403–e1408


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