Beta-amyrin synthase

Beta-amyrin synthase
Identifiers
EC number	5.4.99.39
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Beta-amyrin synthase (EC 5.4.99.39, 2,3-oxidosqualene beta-amyrin cyclase, AsbAS1, BPY, EtAS, GgbAS1, LjAMY1, MtAMY1, PNY, BgbAS) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-amyrin-forming).^{[1][2][3][4][5][6][7][8][9][10][11]} This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene $\rightleftharpoons$ beta-amyrin

Some organism possess a monofunctional beta-amyrin synthase.

References

1. Abe, I, Ebizuka, Y., Seo, S. and Sankawa, U. (1989). "Purification of squalene-2,3-epoxide cyclases from cell suspension cultures of Rabdosia japonica Hara". FEBS Lett. 249: 100–104. doi:10.1016/0014-5793(89)80024-9.
2. Abe, I., Sankawa, U. and Ebizuka, Y. (1989). "Purification of 2,3-oxdosqualene:β-amyrin cyclase from pea seedlings". Chem. Pharm. Bull. 37: 536–. doi:10.1248/cpb.37.536.
3. Kushiro, T., Shibuya, M. and Ebizuka, Y. (1998). "β-Amyrin synthase-cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants". Eur. J. Biochem. 256: 238–244. doi:10.1046/j.1432-1327.1998.2560238.x. PMID 9746369.
4. Hayashi, H., Huang, P., Kirakosyan, A., Inoue, K., Hiraoka, N., Ikeshiro, Y., Kushiro, T., Shibuya, M. and Ebizuka, Y. (2001). "Cloning and characterization of a cDNA encoding β-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice". Biol. Pharm. Bull. 24: 912–916. doi:10.1248/bpb.24.912. PMID 11510484.
5. Husselstein-Muller, T., Schaller, H. and Benveniste, P. (2001). "Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana". Plant Mol. Biol. 45: 75–92. doi:10.1023/A:1006476123930. PMID 11247608.
6. Iturbe-Ormaetxe, I., Haralampidis, K., Papadopoulou, K. and Osbourn, A.E. (2003). "Molecular cloning and characterization of triterpene synthases from Medicago truncatula and Lotus japonicus". Plant Mol. Biol. 51: 731–743. doi:10.1023/a:1022519709298. PMID 12683345.
7. Zhang, H., Shibuya, M., Yokota, S. and Ebizuka, Y. (2003). "Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants". Biol. Pharm. Bull. 26: 642–650. doi:10.1248/bpb.26.642. PMID 12736505.
8. Hayashi, H., Huang, P., Takada, S., Obinata, M., Inoue, K., Shibuya, M. and Ebizuka, Y. (2004). "Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra". Biol. Pharm. Bull. 27: 1086–1092. doi:10.1248/bpb.27.1086. PMID 15256745.
9. Kajikawa, M., Yamato, K.T., Fukuzawa, H., Sakai, Y., Uchida, H. and Ohyama, K. (2005). "Cloning and characterization of a cDNA encoding β-amyrin synthase from petroleum plant Euphorbia tirucalli L". Phytochemistry 66: 1759–1766. doi:10.1016/j.phytochem.2005.05.021. PMID 16005035.
10. Basyuni, M., Oku, H., Tsujimoto, E., Kinjo, K., Baba, S. and Takara, K. (2007). "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae". FEBS J. 274: 5028–5042. doi:10.1111/j.1742-4658.2007.06025.x. PMID 17803686.
11. Liu, Y., Cai, Y., Zhao, Z., Wang, J., Li, J., Xin, W., Xia, G. and Xiang, F. (2009). "Cloning and functional analysis of a β-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM". Biol. Pharm. Bull. 32: 818–824. doi:10.1248/bpb.32.818. PMID 19420748.

External links

• Beta-amyrin synthase at the US National Library of Medicine Medical Subject Headings (MeSH)