Beta-carotene 15,15'-dioxygenase

Beta-carotene 15,15'-dioxygenase
Identifiers
EC number	1.13.11.63
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Beta-carotene 15,15'-dioxygenase (EC 1.13.11.63, blh (gene)) is an enzyme with systematic name beta-carotene:oxygen 15,15'-dioxygenase (bond-cleaving).^[1][2] This enzyme catalyses the following chemical reaction

beta-carotene + O₂ $\rightleftharpoons$ 2 all-trans-retinal

Beta-carotene 15,15'-dioxygenase contains Fe²⁺.

References

1. Kim, Y.S., Kim, N.H., Yeom, S.J., Kim, S.W. and Oh, D.K. (2009). "In vitro characterization of a recombinant Blh protein from an uncultured marine bacterium as a β-carotene 15,15′-dioxygenase". J. Biol. Chem. 284: 15781–15793. doi:10.1074/jbc.M109.002618. PMC 2708875. PMID 19366683.
2. Kim, Y.S., Park, C.S. and Oh, D.K. (2010). "Retinal production from β-carotene by β-carotene 15,15′-dioxygenase from an unculturable marine bacterium". Biotechnol. Lett. 32 (7): 957–961. doi:10.1007/s10529-010-0239-3. PMID 20229064.

External links

• Beta-carotene 15,15'-dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)