Biotin-dependent malonate decarboxylase

Biotin-dependent malonate decarboxylase
Identifiers
EC number	4.1.1.89
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Biotin-dependent malonate decarboxylase (EC 4.1.1.89, malonate decarboxylase (with biotin), malonate decarboxylase) is an enzyme with systematic name malonate carboxy-lyase (biotin-dependent).^{[1][2][3][4][5][6][7]} This enzyme catalyses the following chemical reaction

malonate + H⁺ $\rightleftharpoons$ acetate + CO₂

Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes.

References

1. Hilbi, H., Dehning, I., Schink, B. and Dimroth, P. (1992). "Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme". Eur. J. Biochem. 207: 117–123. doi:10.1111/j.1432-1033.1992.tb17028.x. PMID 1628643.
2. Hilbi, H. and Dimroth, P. (1994). "Purification and characterization of a cytoplasmic enzyme component of the Na⁺-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase". Arch. Microbiol. 162: 48–56. doi:10.1007/bf00264372. PMID 18251085.
3. Berg, M., Hilbi, H. and Dimroth, P. (1996). "The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2′-(5"-phosphoribosyl)-3′-dephosphocoenzyme A as a prosthetic group". Biochemistry 35: 4689–4696. doi:10.1021/bi952873p. PMID 8664258.
4. Berg, M., Hilbi, H. and Dimroth, P. (1997). "Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na⁺ pump and evidence for their function". Eur. J. Biochem. 245: 103–115. doi:10.1111/j.1432-1033.1997.00103.x. PMID 9128730.
5. Micklefield, J., Harris, K.J., Gröger, S., Mocek, U., Hilbi, H., Dimroth, P. and Floss, H.G. (1995). "Stereochemical course of malonate decarboxylase in Malonomonas rubra has biotin decarboxylation with retention". J. Am. Chem. Soc. 117: 1153–1154. doi:10.1021/ja00108a042.
6. Kim, Y.S. (2002). "Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application". J. Biochem. Mol. Biol. 35: 443–451. doi:10.5483/bmbrep.2002.35.5.443. PMID 12359084.
7. Dimroth, P. and Hilbi, H. (1997). "Enzymic and genetic basis for bacterial growth on malonate". Mol. Microbiol. 25: 3–10. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724.

External links

• Biotin-dependent malonate decarboxylase at the US National Library of Medicine Medical Subject Headings (MeSH)