Biotin-independent malonate decarboxylase

Biotin-independent malonate decarboxylase
Identifiers
EC number	4.1.1.88
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Biotin-independent malonate decarboxylase (EC 4.1.1.88, malonate decarboxylase (without biotin), malonate decarboxylase, MDC) is an enzyme with systematic name malonate carboxy-lyase (biotin-independent).^{[1][2][3][4][5][6][7][8][9]} This enzyme catalyses the following chemical reaction

malonate + H⁺ $\rightleftharpoons$ acetate + CO₂

Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes.

References

1. Schmid, M., Berg, M., Hilbi, H. and Dimroth, P. (1996). "Malonate decarboxylase of Klebsiella pneumoniae catalyses the turnover of acetyl and malonyl thioester residues on a coenzyme-A-like prosthetic group". Eur. J. Biochem. 237: 221–228. doi:10.1111/j.1432-1033.1996.0221n.x. PMID 8620876.
2. Byun, H.S. and Kim, Y.S. (1997). "Subunit organization of bacterial malonate decarboxylases: the smallest δ subunit as an acyl-carrier protein". J. Biochem. Mol. Biol. 30: 132–137.
3. Hoenke, S., Schmid, M. and Dimroth, P. (1997). "Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli". Eur. J. Biochem. 246: 530–538. doi:10.1111/j.1432-1033.1997.00530.x. PMID 9208947.
4. Chohnan, S., Fujio, T., Takaki, T., Yonekura, M., Nishihara, H. and Takamura, Y. (1998). "Malonate decarboxylase of Pseudomonas putida is composed of five subunits". FEMS Microbiol. Lett. 169: 37–43. doi:10.1111/j.1574-6968.1998.tb13296.x. PMID 9851033.
5. Hoenke, S., Schmid, M. and Dimroth, P. (2000). "Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases". Biochemistry 39: 13233–13240. doi:10.1021/bi001154u. PMID 11052676.
6. Handa, S., Koo, J.H., Kim, Y.S. and Floss, H.G. (1999). "Stereochemical course of biotin-independent malonate decarboxylase catalysis". Arch. Biochem. Biophys. 370: 93–96. doi:10.1006/abbi.1999.1369. PMID 10496981.
7. Koo, J.H. and Kim, Y.S. (1999). "Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus". Eur. J. Biochem. 266: 683–690. doi:10.1046/j.1432-1327.1999.00924.x. PMID 10561613.
8. Kim, Y.S. (2002). "Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application". J. Biochem. Mol. Biol. 35: 443–451. doi:10.5483/bmbrep.2002.35.5.443. PMID 12359084.
9. Dimroth, P. and Hilbi, H. (1997). "Enzymic and genetic basis for bacterial growth on malonate". Mol. Microbiol. 25: 3–10. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724.

External links

• Biotin-independent malonate decarboxylase at the US National Library of Medicine Medical Subject Headings (MeSH)