Brachyurin

Brachyurin
Identifiers
EC number 3.4.21.32
CAS number 848900-32-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Brachyurin (EC 3.4.21.32, Uca pugilator collagenolytic proteinase, crab protease I, crab protease II) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins, with broad specificity for peptide bonds. Native collagen is cleaved about 75% of the length of the molecule from the N-terminus.

This enzyme is isolated from hepatopancreas of the fiddler crab, Uca pugilator.

References

  1. ↑ Hurion, N., Fromentin, H. and Keil, B. (1979). "Specificity of the collagenolytic enzyme from the fungus Entomophthora coronata: comparison with the bacterial collagenase from Achromobacter iophagus". Arch. Biochem. Biophys. 192: 438–445. doi:10.1016/0003-9861(79)90113-9. PMID 219780.
  2. ↑ Grant, G.A., Eisen, A.Z. and Bradshaw, R.A. (1981). "Collagenolytic protease from fiddler crab (Uca pugilator)". Methods Enzymol. 80: 722–734. doi:10.1016/s0076-6879(81)80055-9.
  3. ↑ Welgus, H.G., Grant, G.A., Jeffrey, J.J. and Eisen, A.Z. (1982). "Substrate specificity of the collagenolytic serine protease from Uca pugilator: studies with collagenous substrates". Biochemistry 21: 5183–5189. doi:10.1021/bi00264a012. PMID 6756469.
  4. ↑ Welgus, H.G. and Grant, G.A. (1983). "Degradation of collagen substrates by a trypsin-like serine protease form the fiddler crab Uca pugilator". Biochemistry 22: 2228–2233. doi:10.1021/bi00278a026. PMID 6305411.
  5. ↑ Klimova, O.A., Borukhov, S.I., Solovyeva, N.I., Balaevskaya, T.O. and Strongin, A.Y. (1990). "The isolation and properties of collagenolytic proteases from crab hepatopancreas". Biochem. Biophys. Res. Commun. 166: 1411–1420. doi:10.1016/0006-291x(90)91024-m. PMID 2154979.
  6. ↑ Lu, P.-J., Liu, H.-C. and Tsai, I.-H. (1990). "The midgut trypsins of shrimp (Penaeus monodon). High efficiency toward native protein substrates including collagens". Biol. Chem. Hoppe-Seyler 371: 851–859. doi:10.1515/bchm3.1990.371.2.851. PMID 1963309.

External links

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