Broadly neutralizing HIV-1 antibodies

Broadly Neutralizing HIV-1 Antibodies (bNAbs) are neutralizing antibodies which neutralize multiple HIV-1 viral strains.^[1] In contrast, non-bNAbs are specific for individual viral strains. The discovery of bNAbs has led to an important area of research, namely, discovery of a vaccine, not only limited to HIV, but also other rapidly mutating viruses like Influenza, etc.

The following table shows the characteristics of various HIV-1 bNAbs^[2]

Viral Epitope	Antibody binding characteristics	Antibody clonal family	Year published
MPER of gp41	Contiguous sequence	2F5	1992
	Contiguous sequence	4E10	1994
	Contiguous sequence	M66.6	2011
	Contiguous sequence	CAP206-CH12	2011
	Contiguous sequence	10E8 l	2012
V1V2-glycan	Peptidoglycan	PG9, PG16	2009
	Peptidoglycan	CH01–04	2011
	Peptidoglycan	PGT 141–145	2011
Outer domain glycan	Glycan only	2G12	1994
V3-glycan	Peptidoglycan	PGT121–123	2011
	Peptidoglycan	PGT125–131	2011
	Peptidoglycan	PGT135–137	2011
CD4 binding site	CDRH3 loop	b12	1991
	No liganded structure	HJ16	2010
	CDRH3 loop	CH103–106	2013
	Mimics CD4 via CDRH2	VRC01–03	2010
	Mimics CD4 via CDRH2	VRC-PG04, 04b	2011
	Mimics CD4 via CDRH2	VRC-CH30–34	2011
	No liganded structure	3BNC117, 3BNC60	2011
	Mimics CD4 via CDRH2	NIH45–46	2011
	No liganded structure	12A12, 12A21	2011
	No liganded structure	8ANC131, 134	2011
	No liganded structure	1NC9, 1B2530	2011

Recent years have seen an increase in HIV-1 bNAb discovery.

Online databases like bNAber and LANL constantly report and update the discovery of new HIV bNAbs.

References

1. ↑ ^ Eroshkin AM, Leblanc A, Weekes D, Post K, Li Z, Rajput A, Butera ST, Burton DR, Godzik A. bNAber: database of broadly neutralizing HIV antibodies. Nucleic Acids Research Database issue Volume 42 Issue D1 1 January 2014 PubMed PMID 24214957.
2. ↑ HIV-1 neutralizing antibodies: understanding nature's pathways PMID 23772623)

External links

• bNAber, Database of Broadly Neutralizing HIV-1 Antibodies (bNAbs)
• LANL Antibody Database