Bufalin

Bufalin, is a cardiotonic steroid originally isolated from the Chinese toad venom. It is a component found in many chinese traditional medicine.[1]

Usage

Researches showed that Bufalin has an antitumor effect against various malignancies, such as: hepatocellular [2] and lung carcinoma [3] However, as with other bufadienolides, its use is hampered by its cardiotoxicity.[4]

Notes and references

  1. ↑ "Datasheet: Bufotalin sc-sc-200136" Santa Cruz Biotechnology, Inc.http://datasheets.scbt.com/sc-200136.pdf
  2. ↑ Zhang ZJ (Feb 2014). "Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice.". J Transl Med. 12: 57. doi:10.1186/1479-5876-12-57. PMC 4015709. PMID 24581171.
  3. ↑ Wu SH (2014). "Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways.". Am J Chin Med. 42 (3): 729–42. doi:10.1142/S0192415X14500475. PMID 24871662.
  4. ↑ Ma H (Jul 2012). "The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice.". Exp Toxicol Pathol. 64 (5): 417–23. doi:10.1016/j.etp.2010.10.007. PMID 21084181.
This article is issued from Wikipedia - version of the Sunday, November 09, 2014. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.