Butein

Butein
Names
IUPAC name
(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
Other names
2',3,4,4'-Tetrahydroxychalcone
2',4',3,4-Tetrahydroxychalcone
3,4,2',4'-Tetrahydroxychalcone
2′,4′,3,4-Tetrahydroxychalcone
Identifiers
487-52-5 YesY
21849-70-7
ChEMBL ChEMBL128000 YesY
ChemSpider 4444634 YesY
Jmol interactive 3D Image
PubChem 5281222
Properties
C15H12O5
Molar mass 272.25 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Butein is a chalconoid. It can be found in Toxicodendron vernicifluum (or formerly Rhus verniciflua). It has antioxidative, aldose reductase and advanced glycation endproducts inhibitory effects.[1] It is also a sirtuin-activating compound, a chemical compound having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. It turned out that buteins possess a high ability to inhibit aromatase process in the human body, for this reason, the use of these compounds in the treatment of breast cancer on the estrogen ground has been taken into account.[2] The first attempts of sport pro-hormone supplementation with the use of buteins took place in Poland.[3]

References


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