Butyrophilin, subfamily 2, member A2

Butyrophilin, subfamily 2, member A2
Identifiers
Symbols	BTN2A2 ; BT2.2; BTF2; BTN2.2
External IDs	OMIM: 613591 MGI: 3606486 HomoloGene: 56012 GeneCards: BTN2A2 Gene
Gene ontology Molecular function • protein binding Cellular component • integral component of membrane • extracellular exosome Biological process • negative regulation of cellular metabolic process • negative regulation of activated T cell proliferation • negative regulation of cytokine secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10385	238555
Ensembl	ENSG00000124508	ENSMUSG00000053216
UniProt	Q8WVV5	A4QPC6
RefSeq (mRNA)	NM_001197237	NM_001289614
RefSeq (protein)	NP_001184166	NP_001276543
Location (UCSC)	Chr 6: 26.38 – 26.39 Mb	Chr 13: 23.48 – 23.49 Mb
PubMed search

Butyrophilin subfamily 2 member A2 is a protein that in humans is encoded by the BTN2A2 gene.^[1][2][3]

Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type 1 receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.^[3]

References

1. Henry J, Miller MM, Pontarotti P (Jul 1999). "Structure and evolution of the extended B7 family". Immunol Today 20 (6): 285–8. doi:10.1016/S0167-5699(98)01418-2. PMID 10354554.
2. Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R Jr, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN (Aug 1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Res 7 (5): 441–56. doi:10.1101/gr.7.5.441. PMID 9149941.
3. "Entrez Gene: BTN2A2 butyrophilin, subfamily 2, member A2".

Further reading

• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cavaletto M, Giuffrida MG, Fortunato D; et al. (2003). "A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane.". Proteomics 2 (7): 850–6. doi:10.1002/1615-9861(200207)2:7<850::AID-PROT850>3.0.CO;2-C. PMID 12124930.
• Rhodes DA, Stammers M, Malcherek G; et al. (2001). "The cluster of BTN genes in the extended major histocompatibility complex.". Genomics 71 (3): 351–62. doi:10.1006/geno.2000.6406. PMID 11170752.

External links

• BTN2A2 human gene location in the UCSC Genome Browser.
• BTN2A2 human gene details in the UCSC Genome Browser.