C-terminal processing peptidase

C-terminal processing peptidase
Identifiers
EC number	3.4.21.102
CAS number	92480-11-0&title= 216484-75-2, 92480-11-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

C-terminal processing peptidase (EC 3.4.21.102, CtpA gene product (Synechocystis sp.), photosystem II D1 protein processing peptidase, protease Re, tail-specific protease, Tsp protease) is an enzyme.^[1][2][3] This enzyme catalyses the following chemical reaction

The enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala!Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. In the plant chloroplast, the enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II

Proteolytic processing of the D1 protein of photosystem II anables light-driven assembly of the tetranuclear manganese cluster.

References

1. Keiler, K.C. and Sauer, R.T. (1998). "Tsp protease". In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 460–461.
2. Beebe, K.D., Shin, J.N., Peng, J., Chaudhury, C., Khera, J. and Pei, D.H. (2000). "Substrate recognition through a PDZ domain in tail-specific protease". Biochemistry 39 (11): 3149–3155. doi:10.1021/bi992709s. PMID 10715137.
3. Liao, D.I., Qian, J., Chisholm, D.A., Jordan, D.B. and Diner, B.A. (2000). "Crystal structures of the photosystem II D1 C-terminal processing protease". Nat. Struct. Biol. 7 (9): 749–753. doi:10.1038/78973. PMID 10966643.

External links

• C-terminal processing peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)