C1D

C1D nuclear receptor corepressor
Identifiers
Symbols	C1D ; LRP1; Rrp47; SUN-CoR; SUNCOR; hC1D
External IDs	OMIM: 606997 HomoloGene: 4619 GeneCards: C1D Gene
Gene ontology Molecular function • DNA binding • transcription corepressor activity • RNA binding • protein binding • ligand-dependent nuclear receptor binding Cellular component • nuclear exosome (RNase complex) • nucleus • nucleolus • cytoplasm • transcriptional repressor complex Biological process • maturation of 5.8S rRNA • transcription, DNA-templated • apoptotic process • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10438	57316
Ensembl	ENSG00000197223	ENSMUSG00000000581
UniProt	Q13901	O35473
RefSeq (mRNA)	NM_001190263	NM_020558
RefSeq (protein)	NP_001177192	NP_065583
Location (UCSC)	Chr 2: 68.04 – 68.11 Mb	Chr 11: 17.26 – 17.27 Mb
PubMed search

Nuclear nucleic acid-binding protein C1D is a protein that in humans is encoded by the C1D gene.^{[1][2][3][4][5][6]}

Function

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined.^[6]

Interactions

C1D has been shown to interact with TSNAX^[7] and DNA-PKcs.^[8]

References

1. Nehls P, Keck T, Greferath R, Spiess E, Glaser T, Rothbarth K, Stammer H, Werner D (Apr 1998). "cDNA cloning, recombinant expression and characterization of polypetides with exceptional DNA affinity". Nucleic Acids Res. 26 (5): 1160–6. doi:10.1093/nar/26.5.1160. PMC 147382. PMID 9469821.
2. Schilders G, Egberts WV, Raijmakers R, Pruijn GJ (Jul 2007). "C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome". Arthritis Rheum. 56 (7): 2449–54. doi:10.1002/art.22710. PMID 17599775.
3. Schilders G, van Dijk E, Pruijn GJ (May 2007). "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing". Nucleic Acids Res. 35 (8): 2564–72. doi:10.1093/nar/gkm082. PMC 1885644. PMID 17412707.
4. Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". J. Cell. Sci. 115 (Pt 1): 207–16. PMID 11801738.
5. Zamir I, Dawson J, Lavinsky RM, Glass CK, Rosenfeld MG, Lazar MA (Feb 1998). "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14400–5. doi:10.1073/pnas.94.26.14400. PMC 24996. PMID 9405624. Check date values in: |year= / |date= mismatch (help)
6. "Entrez Gene: C1D nuclear DNA-binding protein".
7. Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". J. Cell. Sci. 115 (Pt 1): 207–16. PMID 11801738.
8. Yavuzer U, Smith GC, Bliss T, Werner D, Jackson SP (Jul 1998). "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D". Genes Dev. 12 (14): 2188–99. doi:10.1101/gad.12.14.2188. PMC 317006. PMID 9679063.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Rothbarth K, Stammer H, Werner D (2002). "Proteasome-mediated degradation antagonizes critical levels of the apoptosis-inducing C1D protein". Cancer Cell Int. 2 (1): 12. doi:10.1186/1475-2867-2-12. PMC 140130. PMID 12379155.
• Rothbarth K, Hunziker A, Stammer H, Werner D (2001). "Promoter of the gene encoding the 16 kDa DNA-binding and apoptosis-inducing C1D protein". Biochim. Biophys. Acta 1518 (3): 271–5. doi:10.1016/S0167-4781(01)00198-1. PMID 11311939.
• Rothbarth K, Spiess E, Juodka B, Yavuzer U, Nehls P, Stammer H, Werner D (1999). "Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D". J. Cell. Sci. 112 ( Pt 13) (13): 2223–32. PMID 10362552.
• Haataja L, Groffen J, Heisterkamp N (1998). "Identification of a novel Rac3-interacting protein C1D". Int. J. Mol. Med. 1 (4): 665–70. doi:10.3892/ijmm.1.4.665. PMID 9852280.
• Yavuzer U, Smith GC, Bliss T, Werner D, Jackson SP (1998). "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D". Genes Dev. 12 (14): 2188–99. doi:10.1101/gad.12.14.2188. PMC 317006. PMID 9679063.