C1QTNF1

C1q and tumor necrosis factor related protein 1
Identifiers
Symbols	C1QTNF1 ; CTRP1; GIP; ZSIG37
External IDs	OMIM: 610365 MGI: 1919254 HomoloGene: 10548 GeneCards: C1QTNF1 Gene
Gene ontology Molecular function • protein binding • collagen binding Cellular component • collagen trimer • extracellular space • cytosol • integral component of plasma membrane Biological process • positive regulation of cytosolic calcium ion concentration • negative regulation of platelet activation • positive regulation of gene expression • regulation of glucose metabolic process • positive regulation of MAPK cascade • protein homooligomerization • positive regulation of protein kinase B signaling • protein heterotrimerization • negative regulation of platelet aggregation • positive regulation of aldosterone secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	114897	56745
Ensembl	ENSG00000173918	ENSMUSG00000017446
UniProt	Q9BXJ1	Q9QXP7
RefSeq (mRNA)	NM_030968	NM_001204129
RefSeq (protein)	NP_112230	NP_001191058
Location (UCSC)	Chr 17: 79.02 – 79.05 Mb	Chr 11: 118.43 – 118.45 Mb
PubMed search

Complement C1q tumor necrosis factor-related protein 1 is a protein that in humans is encoded by the C1QTNF1 gene.^[1][2]

Interactions

C1QTNF1 has been shown to interact with Arginine vasopressin receptor 2.^[3]

References

1. Innamorati G, Whang MI, Molteni R, Le Gouill C, Birnbaumer M (Oct 2002). "GIP, a G-protein-coupled receptor interacting protein". Regul Pept 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. PMID 12409230.
2. "Entrez Gene: C1QTNF1 C1q and tumor necrosis factor related protein 1".
3. Innamorati, Giulio; Whang Michael Insuk; Molteni Raffaella; Le Gouill Christian; Birnbaumer Mariel (Nov 2002). "GIP, a G-protein-coupled receptor interacting protein". Regul. Pept. (Netherlands) 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. ISSN 0167-0115. PMID 12409230.

Further reading

• Innamorati G, Bianchi E, Whang MI. (2006). "An intracellular role for the C1q-globular domain". Cell Signal. 18 (6): 761–70. doi:10.1016/j.cellsig.2005.11.004. PMID 16386877.

• Kim KY, Kim HY, Kim JH; et al. (2006). "Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue". FEBS Lett. 580 (16): 3953–60. doi:10.1016/j.febslet.2006.06.034. PMID 16806199.
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.