C21orf33

Chromosome 21 open reading frame 33
Identifiers
Symbols	C21orf33 ; ES1; GT335; HES1; KNPH; KNPI
External IDs	OMIM: 601659 MGI: 1351861 HomoloGene: 3416 GeneCards: C21orf33 Gene
Gene ontology Cellular component • mitochondrion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8209	28295
Ensembl	ENSG00000160221	ENSMUSG00000053329
UniProt	P30042	Q9D172
RefSeq (mRNA)	NM_004649	NM_138601
RefSeq (protein)	NP_004640	NP_613067
Location (UCSC)	Chr 21: 44.13 – 44.15 Mb	Chr 10: 78.16 – 78.17 Mb
PubMed search

ES1 protein homolog, mitochondrial is a protein that in humans is encoded by the C21orf33 gene.^[1][2][3]

References

1. Scott HS, Chen H, Rossier C, Lalioti MD, Antonarakis SE (Jun 1997). "Isolation of a human gene (HES1) with homology to an Escherichia coli and a zebrafish protein that maps to chromosome 21q22.3". Hum Genet 99 (5): 616–23. doi:10.1007/s004390050416. PMID 9150728.
2. Lafreniere RG, Rochefort DL, Kibar Z, Fon EA, Han F, Cochius J, Kang X, Baird S, Korneluk RG, Andermann E, Rommens JM, Rouleau GA (Mar 1997). "Isolation and characterization of GT335, a novel human gene conserved in Escherichia coli and mapping to 21q22.3". Genomics 38 (3): 264–72. doi:10.1006/geno.1996.0627. PMID 8975701.
3. "Entrez Gene: C21orf33 chromosome 21 open reading frame 33".

Further reading

• Hochstrasser DF, Frutiger S, Paquet N; et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison.". Electrophoresis 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669.
• Nagamine K, Kudoh J, Minoshima S; et al. (1996). "Isolation of cDNA for a novel human protein KNP-I that is homologous to the E. coli SCRP-27A protein from the autoimmune polyglandular disease type I (APECED) region of chromosome 21q22.3.". Biochem. Biophys. Res. Commun. 225 (2): 608–16. doi:10.1006/bbrc.1996.1218. PMID 8753807.
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Kudoh J, Nagamine K, Asakawa S; et al. (1997). "Localization of 16 exons to a 450-kb region involved in the autoimmune polyglandular disease type I (APECED) on human chromosome 21q22.3.". DNA Res. 4 (1): 45–52. doi:10.1093/dnares/4.1.45. PMID 9179495.
• Nagamine K, Kudoh J, Minoshima S; et al. (1997). "Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21.". Genomics 42 (3): 528–31. doi:10.1006/geno.1997.4761. PMID 9205129.
• Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
• Yan B, Raben N, Plotz P (2002). "The human acid alpha-glucosidase gene is a novel target of the Notch-1/Hes-1 signaling pathway.". J. Biol. Chem. 277 (33): 29760–4. doi:10.1074/jbc.M204721200. PMID 12065598.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shin JH, Weitzdoerfer R, Fountoulakis M, Lubec G (2004). "Expression of cystathionine beta-synthase, pyridoxal kinase, and ES1 protein homolog (mitochondrial precursor) in fetal Down syndrome brain.". Neurochem. Int. 45 (1): 73–9. doi:10.1016/j.neuint.2003.12.004. PMID 15082224.
• Hartman J, Müller P, Foster JS; et al. (2005). "HES-1 inhibits 17beta-estradiol and heregulin-beta1-mediated upregulation of E2F-1.". Oncogene 23 (54): 8826–33. doi:10.1038/sj.onc.1208139. PMID 15467735.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.