C2orf28

All-trans retinoic acid-induced differentiation factor
Identifiers
Symbols	ATRAID ; APR--3; APR-3; APR3; C2orf28; HSPC013; PRO240; p18
External IDs	MGI: 1918918 HomoloGene: 15412 GeneCards: ATRAID Gene
Gene ontology Molecular function • molecular_function • protein binding Cellular component • nuclear envelope • plasma membrane • integral component of membrane • perinuclear region of cytoplasm Biological process • regulation of gene expression • cell differentiation • positive regulation of bone mineralization • negative regulation of osteoblast proliferation • positive regulation of osteoblast differentiation • negative regulation of cyclin catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51374	381629
Ensembl	ENSG00000138085	ENSMUSG00000013622
UniProt	Q6UW56	Q6PGD0
RefSeq (mRNA)	NM_001170795	NM_027855
RefSeq (protein)	NP_001164266	NP_082131
Location (UCSC)	Chr 2: 27.21 – 27.22 Mb	Chr 5: 31.05 – 31.05 Mb
PubMed search

Apoptosis-related protein 3 is a protein that in humans is encoded by the C2orf28 gene.^[1][2][3]

This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[3]

References

1. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
2. Zhu F, Yan W, Zhao ZL, Chai YB, Lu F, Wang Q, Peng WD, Yang AG, Wang CJ (Nov 2000). "Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes". Biotechniques 29 (2): 310–3. PMID 10948432.
3. "Entrez Gene: C2orf28 chromosome 2 open reading frame 28".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Yang G, Yu F, Fu H; et al. (2007). "Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB.". Mol. Cell. Biochem. 302 (1-2): 187–94. doi:10.1007/s11010-007-9440-7. PMID 17387583.
• Yu F, Yang G, Zhao Z; et al. (2007). "Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1.". Biochem. Biophys. Res. Commun. 358 (4): 1041–6. doi:10.1016/j.bbrc.2007.05.049. PMID 17524364.