C3orf60

NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
Identifiers
Symbols	NDUFAF3 ; 2P1; C3orf60; E3-3
External IDs	OMIM: 612911 MGI: 1913956 HomoloGene: 32460 GeneCards: NDUFAF3 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • mitochondrial inner membrane Biological process • mitochondrial respiratory chain complex I assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	25915	66706
Ensembl	ENSG00000178057	ENSMUSG00000070283
UniProt	Q9BU61	Q9JKL4
RefSeq (mRNA)	NM_199069	NM_023247
RefSeq (protein)	NP_951032	NP_075736
Location (UCSC)	Chr 3: 49.02 – 49.02 Mb	Chr 9: 108.57 – 108.57 Mb
PubMed search

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 is an enzyme that in humans is encoded by the NDUFAF3 gene.^[1][2][3]

This gene encodes a nuclear protein of unknown function. The similar rat nuclear protein is predominantly expressed in testis. Alternatively spliced transcript variants encoding different isoforms have been identified.^[3]

References

1. Hammami-Hamza S, Doussau M, Allemand I, Segretain D, Gasc JM, Finaz C (Mar 2003). "2P1, a novel male mouse cDNA specifically expressed during meiosis". Int J Dev Biol 47 (1): 71–6. PMID 12653254.
2. Hartmann AM, Stamm S (Nov 1997). "Molecular cloning of a novel alternatively spliced nuclear protein". Biochim Biophys Acta 1353 (3): 224–30. doi:10.1016/s0167-4781(97)00090-0. PMID 9349717.
3. "Entrez Gene: C3orf60 chromosome 3 open reading frame 60".

Further reading

• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.