C5orf3

Family with sequence similarity 114, member A2
Identifiers
Symbols FAM114A2 ; 133K02; C5orf3
External IDs MGI: 1917629 HomoloGene: 10270 GeneCards: FAM114A2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10827 67726
Ensembl ENSG00000055147 ENSMUSG00000020523
UniProt Q9NRY5 Q8VE88
RefSeq (mRNA) NM_018691 NM_001168667
RefSeq (protein) NP_061161 NP_001162138
Location (UCSC) Chr 5:
153.99 – 154.04 Mb
Chr 11:
57.48 – 57.52 Mb
PubMed search

C5orf3 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. This protein has a function that is not well known. C5orf3 is, however, highly conserved in mammals with homologs both in fungi and plants.

Species Accession # Identity
macaca mulatta XM_001102467 78.1%
Pan troglodytes XM_518045 89.7%
bos taurus NP_001033166 85.6%
Pongo abelii XM_002816109 87.8%
Mus musculus NM_026342.3 79%
Callithrix jacchus XP_002744467 94.7%

Protein

The c5orf3 protein is 505 amino acids long[1] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.[2] It is predicted to stay in the nucleus after translation [3] There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 [4] This protein is thought to include a P loop [5] that suggests a role in ATP- and/or GTP-binding [6]

Gene

The c5orf3 gene is located on chromosome 5 (5q31-33).[7] This gene has 14 exons spanning through its sequence.[1] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.[1] It is expressed at high levels in most tissues of the human body.[7] It is also highly expressed in tissues in the human brain [8]

References

  1. 1 2 3 Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI
  2. Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#!
  3. PSORT WWW Server
  4. STRING: http://string-db.org/newstring_cgi/show_network_section.pl.
  5. http://string-db.org/newstring_cgi/show_textmining_evidence.pl.
  6. Saraste M, Sibbald PR, Wittinghofer A (November 1990). "The P-loop--a common motif in ATP- and GTP-binding proteins". Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID 2126155.
  7. 1 2 FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody
  8. Allen Brain Atlas: http://human.brain-map.org/search?type=mi

.

Further reading


This article is issued from Wikipedia - version of the Tuesday, April 12, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.