C5orf3

Family with sequence similarity 114, member A2
Identifiers
Symbols	FAM114A2 ; 133K02; C5orf3
External IDs	MGI: 1917629 HomoloGene: 10270 GeneCards: FAM114A2 Gene
Gene ontology Molecular function • purine nucleotide binding Cellular component • cellular_component Biological process • biological_process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10827	67726
Ensembl	ENSG00000055147	ENSMUSG00000020523
UniProt	Q9NRY5	Q8VE88
RefSeq (mRNA)	NM_018691	NM_001168667
RefSeq (protein)	NP_061161	NP_001162138
Location (UCSC)	Chr 5: 153.99 – 154.04 Mb	Chr 11: 57.48 – 57.52 Mb
PubMed search

C5orf3 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. This protein has a function that is not well known. C5orf3 is, however, highly conserved in mammals with homologs both in fungi and plants.

Species	Accession #	Identity
macaca mulatta	XM_001102467	78.1%
Pan troglodytes	XM_518045	89.7%
bos taurus	NP_001033166	85.6%
Pongo abelii	XM_002816109	87.8%
Mus musculus	NM_026342.3	79%
Callithrix jacchus	XP_002744467	94.7%

Protein

The c5orf3 protein is 505 amino acids long^[1] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.^[2] It is predicted to stay in the nucleus after translation ^[3] There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 ^[4] This protein is thought to include a P loop ^[5] that suggests a role in ATP- and/or GTP-binding ^[6]

Gene

The c5orf3 gene is located on chromosome 5 (5q31-33).^[7] This gene has 14 exons spanning through its sequence.^[1] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.^[1] It is expressed at high levels in most tissues of the human body.^[7] It is also highly expressed in tissues in the human brain ^[8]

References

1. Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI
2. Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#!
3. PSORT WWW Server
4. STRING: http://string-db.org/newstring_cgi/show_network_section.pl.
5. http://string-db.org/newstring_cgi/show_textmining_evidence.pl.
6. Saraste M, Sibbald PR, Wittinghofer A (November 1990). "The P-loop--a common motif in ATP- and GTP-binding proteins". Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID 2126155.
7. FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody
8. Allen Brain Atlas: http://human.brain-map.org/search?type=mi

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Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.