C8orf4

Chromosome 8 open reading frame 4
Identifiers
Symbols	C8orf4 ; TC-1; TC1
External IDs	OMIM: 607702 MGI: 1916318 HomoloGene: 10590 GeneCards: C8orf4 Gene
Gene ontology Molecular function • Notch binding • protein binding Cellular component • nucleus • nucleolus • cytoplasm • nuclear speck Biological process • endothelial cell activation involved in immune response • apoptotic process • cellular response to heat • positive regulation of NF-kappaB import into nucleus • regulation of DNA-templated transcription in response to stress • negative regulation of Notch signaling pathway • regulation of cell cycle G1/S phase transition • regulation of hemopoiesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56892	69068
Ensembl	ENSG00000176907	ENSMUSG00000056313
UniProt	Q9NR00	Q9D915
RefSeq (mRNA)	NM_020130	NM_026931
RefSeq (protein)	NP_064515	NP_081207
Location (UCSC)	Chr 8: 40.15 – 40.16 Mb	Chr 8: 24.44 – 24.44 Mb
PubMed search

Uncharacterized protein C8orf4 is a protein that in humans is encoded by the C8orf4 gene.^[1][2]

This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes.^[2]

References

1. Chua EL, Young L, Wu WM, Turtle JR, Dong Q (Nov 2000). "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer". Genomics 69 (3): 342–7. doi:10.1006/geno.2000.6348. PMID 11056052.
2. "Entrez Gene: C8orf4 chromosome 8 open reading frame 4".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sunde M, McGrath KC, Young L; et al. (2004). "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer.". Cancer Res. 64 (8): 2766–73. doi:10.1158/0008-5472.CAN-03-2093. PMID 15087392.
• Friedman JB, Brunschwig EB, Platzer P; et al. (2004). "C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer.". Int. J. Cancer 111 (1): 72–5. doi:10.1002/ijc.20235. PMID 15185345.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jung Y, Bang S, Choi K; et al. (2006). "TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby.". Cancer Res. 66 (2): 723–8. doi:10.1158/0008-5472.CAN-05-3124. PMID 16424001.
• Kim B, Koo H, Yang S; et al. (2007). "TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer.". Clin. Cancer Res. 12 (11 Pt 1): 3541–8. doi:10.1158/1078-0432.CCR-05-2440. PMID 16740781.
• Yang ZQ, Streicher KL, Ray ME; et al. (2007). "Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.". Cancer Res. 66 (24): 11632–43. doi:10.1158/0008-5472.CAN-06-2946. PMID 17178857.
• Yang ZQ, Moffa AB, Haddad R; et al. (2007). "Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways.". Int. J. Cancer 121 (6): 1265–73. doi:10.1002/ijc.22831. PMID 17520678.
• Park J, Jung Y, Kim J; et al. (2007). "TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response.". Biochem. Biophys. Res. Commun. 360 (2): 447–52. doi:10.1016/j.bbrc.2007.06.077. PMID 17603013.