Calcium-binding protein 1

Calcium binding protein 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2K7B​, 2K7C​, 2K7D​, 2LAN​, 2LAP​, 3OX5​, 3OX6​
Identifiers
Symbols	CABP1 ; CALBRAIN; HCALB_BR
External IDs	OMIM: 605563 HomoloGene: 128292 GeneCards: CABP1 Gene
Gene ontology Molecular function • enzyme inhibitor activity • calcium ion binding • protein binding • nuclear localization sequence binding • protein domain specific binding • type 3 metabotropic glutamate receptor binding • protein homodimerization activity • ion channel binding • calcium-dependent protein binding Cellular component • Golgi membrane • extracellular space • nucleus • cytosol • cytoskeleton • plasma membrane • cell cortex • cytoplasmic side of plasma membrane • postsynaptic density • cell junction • dendrite • neuronal cell body • protein complex • postsynaptic membrane • perinuclear region of cytoplasm Biological process • negative regulation of cell communication by electrical coupling • negative regulation of protein import into nucleus • negative regulation of catalytic activity • negative regulation of voltage-gated calcium channel activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9478	n/a
Ensembl	ENSG00000157782	n/a
UniProt	Q9NZU7	n/a
RefSeq (mRNA)	NM_001033677	n/a
RefSeq (protein)	NP_001028849	n/a
Location (UCSC)	Chr 12: 120.64 – 120.67 Mb	n/a
PubMed search		n/a

Calcium binding protein 1 is a protein that in humans is encoded by the CABP1 gene.^[1] Calcium-binding protein 1 is a calcium-binding protein^[2] discovered in 1999.^[3] It has two EF hand motifs and is expressed in neuronal cells in such areas as hippocampus, habenular nucleus of the epithalamus, Purkinje cell layer of the cerebellum, and the amacrine cells and cone bipolar cells of the retina.

Function

Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein causes rapid inactivation that is independent of Calcium, and does not support Calcium-dependent facilitation (Lee et al., 2002). This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain.^[1]

Cellular expression of caldendrin is restricted to the somato–dendritic compartment, with the exception of hypothalamus, where axonal labeling was detected.^[4]

Clinical significance

In schizophrenia, one study demonstrated a decrease in the number of CABP1-expressing cells, specifically in the left dorsolateral prefrontal cortex. This change, however, was compensated on a whole-brain scale by an increase in the protein levels.^[5]

References

1. "Entrez Gene: Calcium binding protein 1".
2. McCue HV, Haynes JW, Burgoyne RD. (2010). "The diversity of calcium sensor proteins in the regulation of neuronal function.". Cold Spring Harb Perspect Biol. 2 (8): a004085. doi:10.1101/cshperspect.a004085. PMC 2908765. PMID 20668007.
3. Yamaguchi K, Yamaguchi F, Miyamoto O, Sugimoto K, Konishi R, Hatase O, Tokuda M (1999). "Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain". J. Biol. Chem. 274 (6): 3610–6. doi:10.1074/jbc.274.6.3610. PMID 9920909.
4. Bernstein HG, Seidenbecher CI, Smalla KH, Gundelfinger ED, Bogerts B, Kreutz MR (2003). "Distribution and cellular localization of caldendrin immunoreactivity in adult human forebrain". J. Histochem. Cytochem. 51 (8): 1109–12. doi:10.1177/002215540305100816. PMID 12871994.
5. Bernstein HG, Sahin J, Smalla KH, Gundelfinger ED, Bogerts B, Kreutz MR (2007). "A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia". Schizophrenia Research 96 (1–3): 246–56. doi:10.1016/j.schres.2007.05.038. PMID 17719205.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.