CACYBP

Calcyclin binding protein
PDB rendering based on 1x5m.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1X5M​, 2A25​, 2A26​
Identifiers
Symbols	CACYBP ; GIG5; PNAS-107; S100A6BP; SIP
External IDs	OMIM: 606186 MGI: 1270839 HomoloGene: 7649 GeneCards: CACYBP Gene
Gene ontology Molecular function • protein binding • protein homodimerization activity Cellular component • nuclear envelope lumen • nucleoplasm • cytoplasm • beta-catenin destruction complex • neuron projection • cell body • extracellular exosome Biological process • aging • positive regulation of DNA replication • cardiac muscle cell differentiation • response to growth hormone • negative regulation of cell death • cellular response to calcium ion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27101	12301
Ensembl	ENSG00000116161	ENSMUSG00000014226
UniProt	Q9HB71	Q9CXW3
RefSeq (mRNA)	NM_001007214	NM_009786
RefSeq (protein)	NP_001007215	NP_033916
Location (UCSC)	Chr 1: 175 – 175.01 Mb	Chr 1: 160.2 – 160.21 Mb
PubMed search

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.^[1][2][3]

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

CACYBP has been shown to interact with SKP1A^[4] and SIAH1.^[1]

References

1. Matsuzawa SI, Reed JC (Jun 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol Cell 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.
2. Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR (Jan 2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)". J Biol Chem 278 (3): 1837–40. doi:10.1074/jbc.M210263200. PMID 12421809.
3. "Entrez Gene: CACYBP calcyclin binding protein".
4. Matsuzawa, S I; Reed J C (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol. Cell (United States) 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. ISSN 1097-2765. PMID 11389839.

Further reading

• Filipek A, Jastrzebska B, Nowotny M; et al. (2002). "Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells.". J. Biol. Chem. 277 (23): 21103–9. doi:10.1074/jbc.M111010200. PMID 11927578.
• Liu WX, Wu J, Zhao Z; et al. (2003). "[Cloning and expression of human calcyclin binding protein (hCacyBP) gene]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34 (2): 181–6. PMID 12006993.
• Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family.". J. Biol. Chem. 277 (32): 28848–52. doi:10.1074/jbc.M203602200. PMID 12042313.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wu J, Tan X, Peng X; et al. (2004). "Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells.". J. Biochem. Mol. Biol. 36 (4): 354–8. doi:10.5483/bmbrep.2003.36.4.354. PMID 12895292.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Santelli E, Leone M, Li C; et al. (2005). "Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex.". J. Biol. Chem. 280 (40): 34278–87. doi:10.1074/jbc.M506707200. PMID 16085652.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Sun S, Ning X, Liu J; et al. (2007). "Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma.". Biochem. Biophys. Res. Commun. 356 (4): 864–71. doi:10.1016/j.bbrc.2007.03.080. PMID 17400182.