CADM3

Cell adhesion molecule 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1Z9M​
Identifiers
Symbols	CADM3 ; BIgR; IGSF4B; NECL1; Necl-1; TSLL1; synCAM3
External IDs	OMIM: 609743 MGI: 2137858 HomoloGene: 10919 GeneCards: CADM3 Gene
Gene ontology Molecular function • receptor activity • receptor binding • protein homodimerization activity • cell adhesion molecule binding Cellular component • plasma membrane • integral component of plasma membrane • cell-cell junction • cell-cell adherens junction Biological process • homophilic cell adhesion via plasma membrane adhesion molecules • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • cell recognition • protein localization • cell junction assembly • adherens junction organization • cell-cell junction organization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57863	94332
Ensembl	ENSG00000162706	ENSMUSG00000005338
UniProt	Q8N126	Q99N28
RefSeq (mRNA)	NM_001127173	NM_053199
RefSeq (protein)	NP_001120645	NP_444429
Location (UCSC)	Chr 1: 159.17 – 159.2 Mb	Chr 1: 173.33 – 173.37 Mb
PubMed search

Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.^[1][2]

IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005).[supplied by OMIM]^[2]

References

1. Fukuhara H, Kuramochi M, Nobukuni T, Fukami T, Saino M, Maruyama T, Nomura S, Sekiya T, Murakami Y (Sep 2001). "Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins". Oncogene 20 (38): 5401–7. doi:10.1038/sj.onc.1204696. PMID 11536053.
2. "Entrez Gene: CADM3 cell adhesion molecule 3".

Further reading

• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shingai T, Ikeda W, Kakunaga S; et al. (2003). "Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells". J. Biol. Chem. 278 (37): 35421–7. doi:10.1074/jbc.M305387200. PMID 12826663.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Fukami T, Satoh H, Williams YN; et al. (2004). "Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2)". Gene 323: 11–8. doi:10.1016/j.gene.2003.09.018. PMID 14659875.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Kakunaga S, Ikeda W, Itoh S; et al. (2005). "Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes". J. Cell. Sci. 118 (Pt 6): 1267–77. doi:10.1242/jcs.01656. PMID 15741237.
• Zhou Y, Du G, Hu X; et al. (2005). "Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane". Biochim. Biophys. Acta 1669 (2): 142–54. doi:10.1016/j.bbamem.2005.01.013. PMID 15893517.
• Dong X, Xu F, Gong Y; et al. (2006). "Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule". J. Biol. Chem. 281 (15): 10610–7. doi:10.1074/jbc.M513459200. PMID 16467305.
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.