CAND1

Cullin-associated and neddylation-dissociated 1
PDB rendering based on 1u6g.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1U6G​, 4A0C​
Identifiers
Symbols	CAND1 ; TIP120; TIP120A
External IDs	OMIM: 607727 MGI: 1261820 HomoloGene: 10202 GeneCards: CAND1 Gene
Gene ontology Molecular function • protein binding • TBP-class protein binding Cellular component • ubiquitin ligase complex • nucleus • nucleoplasm • cytoplasm • membrane • cullin-RING ubiquitin ligase complex • extracellular exosome Biological process • SCF complex assembly • protein ubiquitination • cell differentiation • negative regulation of catalytic activity • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55832	71902
Ensembl	ENSG00000111530	ENSMUSG00000020114
UniProt	Q86VP6	Q6ZQ38
RefSeq (mRNA)	NM_018448	NM_027994
RefSeq (protein)	NP_060918	NP_082270
Location (UCSC)	Chr 12: 67.27 – 67.32 Mb	Chr 10: 119.2 – 119.24 Mb
PubMed search

Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene.^[1][2][3]

Interactions

CAND1 has been shown to interact with:

• CUL1,^[4][5]
• CUL2,^[4][5]
• CUL3,^[4]
• CUL4A,^[4]
• CUL4B,^[4]
• DCUN1D1,^[6] and
• RBX1.^[4][6]

References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
2. Yogosawa S, Makino Y, Yoshida T, Kishimoto T, Muramatsu M, Tamura T (Dec 1996). "Molecular cloning of a novel 120-kDa TBP-interacting protein". Biochemical and Biophysical Research Communications 229 (2): 612–7. doi:10.1006/bbrc.1996.1852. PMID 8954946.
3. "Entrez Gene: CAND1 cullin-associated and neddylation-dissociated 1".
4. Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". The Journal of Biological Chemistry 278 (18): 15905–10. doi:10.1074/jbc.M213070200. PMID 12609982.
5. Menon S, Tsuge T, Dohmae N, Takio K, Wei N. "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochemistry 9: 1. doi:10.1186/1471-2091-9-1. PMC 2265268. PMID 18173839.
6. Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". The Journal of Biological Chemistry 283 (48): 33211–20. doi:10.1074/jbc.M804440200. PMC 2586271. PMID 18826954.

Further reading

• Yogosawa S, Kayukawa K, Kawata T, Makino Y, Inoue S, Okuda A, Muramatsu M, Tamura T (Dec 1999). "Induced expression, localization, and chromosome mapping of a gene for the TBP-interacting protein 120A". Biochemical and Biophysical Research Communications 266 (1): 123–8. doi:10.1006/bbrc.1999.1773. PMID 10581176.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (Aug 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Liu J, Furukawa M, Matsumoto T, Xiong Y (Dec 2002). "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases". Molecular Cell 10 (6): 1511–8. doi:10.1016/S1097-2765(02)00783-9. PMID 12504025.
• Zheng J, Yang X, Harrell JM, Ryzhikov S, Shim EH, Lykke-Andersen K, Wei N, Sun H, Kobayashi R, Zhang H (Dec 2002). "CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex". Molecular Cell 10 (6): 1519–26. doi:10.1016/S1097-2765(02)00784-0. PMID 12504026.
• Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". The Journal of Biological Chemistry 278 (18): 15905–10. doi:10.1074/jbc.M213070200. PMID 12609982.
• Feng S, Shen Y, Sullivan JA, Rubio V, Xiong Y, Sun TP, Deng XW (Jul 2004). "Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation". The Plant Cell 16 (7): 1870–82. doi:10.1105/tpc.021949. PMC 514167. PMID 15208391.
• Goldenberg SJ, Cascio TC, Shumway SD, Garbutt KC, Liu J, Xiong Y, Zheng N (Nov 2004). "Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases". Cell 119 (4): 517–28. doi:10.1016/j.cell.2004.10.019. PMID 15537541.
• Min KW, Kwon MJ, Park HS, Park Y, Yoon SK, Yoon JB (Sep 2005). "CAND1 enhances deneddylation of CUL1 by COP9 signalosome". Biochemical and Biophysical Research Communications 334 (3): 867–74. doi:10.1016/j.bbrc.2005.06.188. PMID 16036220.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.