CANT1

Calcium activated nucleotidase 1
PDB rendering based on 1s18.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1S18​, 1S1D​, 2H2N​, 2H2U​
Identifiers
Symbols	CANT1 ; DBQD; SCAN-1; SCAN1; SHAPY
External IDs	OMIM: 613165 MGI: 1923275 HomoloGene: 69460 GeneCards: CANT1 Gene
EC number	3.6.1.6
Gene ontology Molecular function • signal transducer activity • calcium ion binding • uridine-diphosphatase activity Cellular component • endoplasmic reticulum membrane • integral component of membrane • Golgi cisterna membrane • extracellular exosome Biological process • signal transduction • proteoglycan biosynthetic process • positive regulation of I-kappaB kinase/NF-kappaB signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	124583	76025
Ensembl	ENSG00000171302	ENSMUSG00000025575
UniProt	Q8WVQ1	Q8VCF1
RefSeq (mRNA)	NM_001159772	NM_001025617
RefSeq (protein)	NP_001153244	NP_001020788
Location (UCSC)	Chr 17: 78.99 – 79.01 Mb	Chr 11: 118.41 – 118.42 Mb
PubMed search

CANT1 is a gene that encodes soluble calcium-activated nucleotidase 1, an enzyme, in humans.^[1][2]

References

1. Failer BU, Braun N, Zimmermann H (Sep 2002). "Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase". J Biol Chem 277 (40): 36978–86. doi:10.1074/jbc.M201656200. PMID 12167635.
2. "Entrez Gene: CANT1 calcium activated nucleotidase 1".

Further reading

• Smith TM, Hicks-Berger CA, Kim S, Kirley TL (2002). "Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases.". Arch. Biochem. Biophys. 406 (1): 105–15. doi:10.1016/S0003-9861(02)00420-4. PMID 12234496.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Murphy DM, Ivanenkov VV, Kirley TL (2003). "Bacterial expression and characterization of a novel, soluble, calcium-binding, and calcium-activated human nucleotidase.". Biochemistry 42 (8): 2412–21. doi:10.1021/bi026763b. PMID 12600208.
• Matsuda A, Suzuki Y, Honda G; et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dai J, Liu J, Deng Y; et al. (2004). "Structure and protein design of a human platelet function inhibitor.". Cell 116 (5): 649–59. doi:10.1016/S0092-8674(04)00172-2. PMID 15006348.
• Yang M, Kirley TL (2004). "Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): identification of residues essential for enzyme activity and the Ca(2+)-induced conformational change.". Biochemistry 43 (28): 9185–94. doi:10.1021/bi049565o. PMID 15248776.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.