CAP2

CAP, adenylate cyclase-associated protein, 2 (yeast)
Identifiers
Symbol	CAP2
External IDs	MGI: 1914502 HomoloGene: 101397 GeneCards: CAP2 Gene
Gene ontology Molecular function • actin binding • protein binding Cellular component • plasma membrane • neuronal postsynaptic density Biological process • cytoskeleton organization • establishment or maintenance of cell polarity • signal transduction • activation of adenylate cyclase activity • axon guidance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10486	67252
Ensembl	ENSG00000112186	ENSMUSG00000021373
UniProt	P40123	Q9CYT6
RefSeq (mRNA)	NM_006366	NM_026056
RefSeq (protein)	NP_006357	NP_080332
Location (UCSC)	Chr 6: 17.39 – 17.56 Mb	Chr 13: 46.5 – 46.65 Mb
PubMed search

Adenylyl cyclase-associated protein 2 is an enzyme that in humans is encoded by the CAP2 gene.^[1][2][3]

Function

This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin.^[3]

Interactions

CAP2 has been shown to interact with CAP1.^[2]

References

1. Yu G, Swiston J, Young D (Jun 1994). "Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins". Journal of Cell Science. 107 ( Pt 6) (6): 1671–8. PMID 7962207.
2. Hubberstey A, Yu G, Loewith R, Lakusta C, Young D (Jun 1996). "Mammalian CAP interacts with CAP, CAP2, and actin". Journal of Cellular Biochemistry 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950.
3. "Entrez Gene: CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)".

Further reading

• Shibata R, Mori T, Du W, Chuma M, Gotoh M, Shimazu M, Ueda M, Hirohashi S, Sakamoto M (Sep 2006). "Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis". Clinical Cancer Research 12 (18): 5363–8. doi:10.1158/1078-0432.CCR-05-2245. PMID 17000669.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.