Calcyphosin

Calcyphosine
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3E3R​
Identifiers
Symbols	CAPS ; CAPS1
External IDs	OMIM: 114212 HomoloGene: 37871 GeneCards: CAPS Gene
Gene ontology Molecular function • calcium ion binding Cellular component • nucleus • cytoplasm • plasma membrane • vesicle • extracellular exosome Biological process • intracellular signal transduction • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	828	n/a
Ensembl	ENSG00000105519	n/a
UniProt	Q13938	n/a
RefSeq (mRNA)	NM_004058	n/a
RefSeq (protein)	NP_004049	n/a
Location (UCSC)	Chr 19: 5.91 – 5.92 Mb	n/a
PubMed search		n/a

Calcyphosin is a protein that in humans is encoded by the CAPS gene.^[1][2][3]

Function

This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants.^[3]

References

1. El Housni H, Radulescu A, Lecocq R, Dumont JE, Christophe D (Aug 1997). "Cloning and sequence analysis of human calcyphosine complementary DNA". Biochim Biophys Acta 1352 (3): 249–52. doi:10.1016/s0167-4781(97)00073-0. PMID 9224948.
2. Lefort A, Passage E, Libert F, Szpirer J, Vassart G, Mattei MG (Feb 1991). "Localization of human calcyphosine gene (CAPS) to the p13.3 region of chromosome 19 by in situ hybridization". Cytogenet Cell Genet 54 (3-4): 154–5. doi:10.1159/000132981. PMID 2265558.
3. "Entrez Gene: CAPS calcyphosine".

Further reading

• Lefort A, Lecocq R, Libert F; et al. (1989). "Cloning and sequencing of a calcium-binding protein regulated by cyclic AMP in the thyroid.". EMBO J. 8 (1): 111–6. PMC 400778. PMID 2540953.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Clément S, Dumont JE, Schurmans S (1997). "Loss of calcyphosine gene expression in mouse and other rodents.". Biochem. Biophys. Res. Commun. 232 (2): 407–13. doi:10.1006/bbrc.1997.6297. PMID 9125191.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.