Caspase recruitment domain-containing protein 8

Caspase recruitment domain family, member 8
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4IKM​
Identifiers
Symbols	CARD8 ; CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN
External IDs	OMIM: 609051 HomoloGene: 136365 GeneCards: CARD8 Gene
Gene ontology Molecular function • protein binding • cysteine-type endopeptidase activator activity involved in apoptotic process • NACHT domain binding • protein homodimerization activity Cellular component • nucleus • nucleoplasm • cytoplasm • NLRP3 inflammasome complex Biological process • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of interleukin-1 beta secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22900	n/a
Ensembl	ENSG00000105483	n/a
UniProt	Q9Y2G2	n/a
RefSeq (mRNA)	NM_001184900	n/a
RefSeq (protein)	NP_001171829	n/a
Location (UCSC)	Chr 19: 48.18 – 48.26 Mb	n/a
PubMed search		n/a

Caspase recruitment domain-containing protein 8 is an protein that in humans is encoded by the CARD8 gene.^[1][2][3]

Function

Caspase recruitment domain (CARD)-containing proteins, such as CARD8, are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NF-κB) in the context of apoptosis or inflammation, respectively.^[3]

References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
2. Pathan N, Marusawa H, Krajewska M, Matsuzawa S, Kim H, Okada K, Torii S, Kitada S, Krajewski S, Welsh K, Pio F, Godzik A, Reed JC (Aug 2001). "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer". J Biol Chem 276 (34): 32220–9. doi:10.1074/jbc.M100433200. PMID 11408476.
3. "Entrez Gene: CARD8 caspase recruitment domain family, member 8".

Further reading

• Fontalba A, Martinez-Taboada V, Gutierrez O; et al. (2007). "Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity.". J. Immunol. 179 (7): 4867–73. doi:10.4049/jimmunol.179.7.4867. PMID 17878386.
• Franke A, Rosenstiel P, Balschun T; et al. (2007). "No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample.". Gastroenterology 132 (5): 2080–1. doi:10.1053/j.gastro.2007.03.087. PMID 17484912.
• McGovern DP, Butler H, Ahmad T; et al. (2006). "TUCAN (CARD8) genetic variants and inflammatory bowel disease.". Gastroenterology 131 (4): 1190–6. doi:10.1053/j.gastro.2006.08.008. PMID 17030188.
• Checinska A, Giaccone G, Hoogeland BS; et al. (2006). "TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells.". BMC Cancer 6: 166. doi:10.1186/1471-2407-6-166. PMC 1538619. PMID 16796750.
• Agostini L, Martinon F, Burns K; et al. (2004). "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.". Immunity 20 (3): 319–25. doi:10.1016/S1074-7613(04)00046-9. PMID 15030775.
• Stilo R, Leonardi A, Formisano L; et al. (2002). "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.". FEBS Lett. 521 (1–3): 165–9. doi:10.1016/S0014-5793(02)02869-7. PMID 12067710.
• Zhang H, Fu W (2002). "NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation". Int. J. Oncol. 20 (5): 1035–40. doi:10.3892/ijo.20.5.1035. PMID 11956601.
• Razmara M, Srinivasula SM, Wang L; et al. (2002). "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis". J. Biol. Chem. 277 (16): 13952–8. doi:10.1074/jbc.M107811200. PMID 11821383.
• Bouchier-Hayes L, Conroy H, Egan H; et al. (2001). "CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways". J. Biol. Chem. 276 (47): 44069–77. doi:10.1074/jbc.M107373200. PMID 11551959.