CASP8AP2

Caspase 8 associated protein 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2LR8​
Identifiers
Symbols	CASP8AP2 ; CED-4; FLASH; RIP25
External IDs	OMIM: 606880 MGI: 1349399 HomoloGene: 8066 GeneCards: CASP8AP2 Gene
Gene ontology Molecular function • DNA binding • transcription corepressor activity • death receptor binding • protein binding • cysteine-type endopeptidase activator activity involved in apoptotic process • peptidase activator activity involved in apoptotic process • SUMO polymer binding Cellular component • nucleus • cytoplasm • mitochondrion • PML body Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • activation of cysteine-type endopeptidase activity involved in apoptotic process • cell cycle • signal transduction • extrinsic apoptotic signaling pathway via death domain receptors • Fas signaling pathway • cellular response to mechanical stimulus • apoptotic signaling pathway • negative regulation of nucleic acid-templated transcription Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9994	26885
Ensembl	ENSG00000118412	ENSMUSG00000028282
UniProt	Q9UKL3	Q9WUF3
RefSeq (mRNA)	NM_001137667	NM_001122978
RefSeq (protein)	NP_001131139	NP_001116450
Location (UCSC)	Chr 6: 89.83 – 89.87 Mb	Chr 4: 32.62 – 32.65 Mb
PubMed search

CASP8-associated protein 2 is a protein that in humans is encoded by the CASP8AP2 gene.^[1][2][3][4]

Function

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.^[4]

Interactions

CASP8AP2 has been shown to interact with TRAF2.^[5]

References

1. Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S (Jun 1999). "The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis". Nature 398 (6730): 777–85. doi:10.1038/19709. PMID 10235259.
2. Milovic-Holm K, Krieghoff E, Jensen K, Will H, Hofmann TG (Jan 2007). "FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies". EMBO J. 26 (2): 391–401. doi:10.1038/sj.emboj.7601504. PMC 1783462. PMID 17245429.
3. Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V (Oct 2006). "FLASH is an essential component of Cajal bodies". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14802–7. doi:10.1073/pnas.0604225103. PMC 1578500. PMID 17003126.
4. "Entrez Gene: CASP8AP2 CASP8 associated protein 2".
5. Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK (Jul 2001). "FLASH coordinates NF-kappa B activity via TRAF2". J. Biol. Chem. 276 (27): 25073–7. doi:10.1074/jbc.M102941200. PMID 11340079.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Koonin EV, Aravind L, Hofmann K, Tschopp J, Dixit VM (1999). "Apoptosis. Searching for FLASH domains". Nature 401 (6754): 662; discussion 662–3. doi:10.1038/44317. PMID 10537104.
• Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK (2001). "FLASH coordinates NF-kappa B activity via TRAF2". J. Biol. Chem. 276 (27): 25073–7. doi:10.1074/jbc.M102941200. PMID 11340079.
• Kino T, Chrousos GP (2003). "Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators". J. Biol. Chem. 278 (5): 3023–9. doi:10.1074/jbc.M209234200. PMID 12477726.
• Jun JI, Chung CW, Lee HJ, Pyo JO, Lee KN, Kim NS, Kim YS, Yoo HS, Lee TH, Kim E, Jung YK (2005). "Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway". Oncogene 24 (4): 688–96. doi:10.1038/sj.onc.1208186. PMID 15592525.
• Kino T, Ichijo T, Chrousos GP (2004). "FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors". J. Steroid Biochem. Mol. Biol. 92 (5): 357–63. doi:10.1016/j.jsbmb.2004.09.003. PMID 15698540.
• Flotho C, Coustan-Smith E, Pei D, Iwamoto S, Song G, Cheng C, Pui CH, Downing JR, Campana D (2006). "Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2". Blood 108 (3): 1050–7. doi:10.1182/blood-2006-01-0322. PMC 1895863. PMID 16627760.
• Barcaroli D, Bongiorno-Borbone L, Terrinoni A, Hofmann TG, Rossi M, Knight RA, Matera AG, Melino G, De Laurenzi V (2006). "FLASH is required for histone transcription and S-phase progression". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14808–12. doi:10.1073/pnas.0604227103. PMC 1578501. PMID 17003125.
• Jeong EG, Lee SH, Lee HW, Soung YH, Yoo NJ, Lee SH (2007). "Immunohistochemical and mutational analysis of FLASH in gastric carcinomas". APMIS 115 (8): 900–5. doi:10.1111/j.1600-0463.2007.apm_706.x. PMID 17696945.

External links

• CASP8AP2 human gene location in the UCSC Genome Browser.
• CASP8AP2 human gene details in the UCSC Genome Browser.