CAZy

This article is about the database. For the community in the United States, see Cazy, West Virginia.
CAZy
Content
Description carbohydrate-active enzymes database
Contact
Research center AFMB, French National Centre for Scientific Research
Laboratory Glycogenomics group
Primary citation Lombard & al. (2014)[1]
Access
Website http://www.cazy.org/
Tools
Web

http://research.ahv.dk/cazy http://mothra.ornl.gov/cgi-bin/cat/cat.cgi

http://csbl.bmb.uga.edu/dbCAN/

CAZy is a database of Carbohydrate-Active enZYmes (CAZymes).[1][2] The database contains a classification and associated information about enzymes involved in the synthesis, metabolism, and transport of carbohydrates. Included in the database are glycoside hydrolases, glycosyltransferases, polysaccharide lyases, carbohydrate esterase and carbohydrate-binding families.

CAZy was established in 1999 in order to provide online and constantly updated access to the family classification of CAZymes.[1] New genomes are added shortly after they appear in the daily releases of GenBank.[3] As of November 2013, CAZy contains sequence information on nearly 340,000 CAZymes.[1]

The CAZy database is coupled with the CAZypedia online encyclopedia, which was launched in June 2009 and intended to be a wiki-based encyclopedia of CAZymes.[4][5] As of 2014, CAZy is developed by the Glycogenomics group at AFMB, a research centre affiliated with the French National Centre for Scientific Research and Aix-Marseille University.[6][7]

Classification

CAZy identifies evolutionary related families of glycosyl hydrolases using the classification introduced by Bernard Henrissat.[8][9] As of 2012 CAZy contains 131 families of glycosyl hydrolase families. These families are given a number to identify them, so for example Glycosyl hydrolase family 1 contains enzymes that possess a TIM barrel fold. These families are clustered into 14 different clans that share structural similarity. CAZy contains 94 families of Glycosyl transferase enzymes,[10] 22 families of polysaccharide lysases[11] and 16 families of carbohydrate esterases.

References

  1. 1 2 3 4 Lombard, V.; Golaconda Ramulu, H.; Drula, E.; Coutinho, P. M.; Henrissat, B. (21 November 2013). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research 42 (D1): D490–D495. doi:10.1093/nar/gkt1178.
  2. ↑ Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, Henrissat B (January 2009). "The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics". Nucleic Acids Res. 37 (Database issue): D233–8. doi:10.1093/nar/gkn663. PMC 2686590. PMID 18838391.
  3. ↑ "CAZy - Home". Retrieved 3 September 2014.
  4. ↑ "CAZypedia:About - CAZypedia". Retrieved 3 September 2014.
  5. ↑ "CAZYpedia:History - CAZypedia". Retrieved 3 September 2014.
  6. ↑ "CAZy - About Us". www.cazy.org. Retrieved 3 September 2014.
  7. ↑ "AFMB UMR 7257 - UMR7257 : CNRS - AIX MARSEILLE UNIV". www.afmb.univ-mrs.fr. Retrieved 3 September 2014.
  8. ↑ Henrissat, B. (1991). "A classification of glycosyl hydrolases based on amino acid sequence similarities". The Biochemical Journal 280 (Pt 2): 309–316. PMC 1130547. PMID 1747104.
  9. ↑ Henrissat, B.; Davies, G. (1997). "Structural and sequence-based classification of glycoside hydrolases". Current Opinion in Structural Biology 7 (5): 637–644. doi:10.1016/S0959-440X(97)80072-3. PMID 9345621.
  10. ↑ Coutinho, P. M.; Deleury, E.; Davies, G. J.; Henrissat, B. (2003). "An evolving hierarchical family classification for glycosyltransferases". Journal of Molecular Biology 328 (2): 307–317. doi:10.1016/S0022-2836(03)00307-3. PMID 12691742.
  11. ↑ Lombard, V.; Bernard, T.; Rancurel, C.; Brumer, H.; Coutinho, P. M.; Henrissat, B. (2010). "A hierarchical classification of polysaccharide lyases for glycogenomics". Biochemical Journal 432 (3): 437–444. doi:10.1042/BJ20101185. PMID 20925655.

External links

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