CBX8

Chromobox homolog 8
PDB rendering based on 2dnv.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3I91​
Identifiers
Symbols	CBX8 ; PC3; RC1
External IDs	MGI: 1353589 HomoloGene: 32199 GeneCards: CBX8 Gene
Gene ontology Molecular function • single-stranded RNA binding • protein binding • methylated histone binding • ubiquitin-protein transferase activator activity Cellular component • nuclear chromatin • heterochromatin • nucleus • nucleoplasm • PcG protein complex • PRC1 complex Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of cell proliferation • histone ubiquitination • protein sumoylation • positive regulation of collagen biosynthetic process • post-translational protein modification • cellular protein metabolic process • positive regulation of DNA repair • regulation of catalytic activity • cellular response to hydrogen peroxide Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57332	30951
Ensembl	ENSG00000141570	ENSMUSG00000025578
UniProt	Q9HC52	Q9QXV1
RefSeq (mRNA)	NM_020649	NM_013926
RefSeq (protein)	NP_065700	NP_038954
Location (UCSC)	Chr 17: 79.79 – 79.8 Mb	Chr 11: 119.04 – 119.04 Mb
PubMed search

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.^[1][2]

Interactions

CBX8 has been shown to interact with RING1^[3] and MLLT1.^[4]

References

1. Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Oct 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J Biol Chem 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164.
2. "Entrez Gene: CBX8 chromobox homolog 8 (Pc class homolog, Drosophila)".
3. Bárdos, J I; Saurin A J; Tissot C; Duprez E; Freemont P S (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J. Biol. Chem. (UNITED STATES) 275 (37): 28785–92. doi:10.1074/jbc.M001835200. ISSN 0021-9258. PMID 10825164.
4. García-Cuéllar, M P; Zilles O; Schreiner S A; Birke M; Winkler T H; Slany R K (Jan 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene (England) 20 (4): 411–9. doi:10.1038/sj.onc.1204108. ISSN 0950-9232. PMID 11313972.

Further reading

• García-Cuéllar MP, Zilles O, Schreiner SA; et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3.". Oncogene 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
• Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias.". Oncogene 20 (29): 3798–805. doi:10.1038/sj.onc.1204478. PMID 11439343.
• Levine SS, Weiss A, Erdjument-Bromage H; et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.". Mol. Cell. Biol. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Obuse C, Yang H, Nozaki N; et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Dietrich N, Bracken AP, Trinh E; et al. (2007). "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.". EMBO J. 26 (6): 1637–48. doi:10.1038/sj.emboj.7601632. PMC 1829390. PMID 17332741.