CCDC11

Coiled-Coil Domain Containing 11, also known as CCDC11 is a protein that is encoded by CCDC11 gene located at chromosome 18 in humans.[1]

Overview

The CCDC11 gene is located on chromosome 18q21.1 and is made of 39303 BP.[2] The CCDC11 protein is made of 514 amino acids and has a mass of 61835 Da.[2] Its aliases include coiled-coil domain containing protein 11, FLJ32743, OTTHUMP00000163503.[2]

Homology

CCDC has orthologs all the way back to betaproteobacteria which is a class of Proteobacteria.[2] The following table represents a small selection of orthologs found using searches in BLAST and BLAT. This is by no means a comprehensive list; however, it shows the diversity of species that CCDC11 is found.

Species Organism Common Name NCBI Accession Length (AAs) Sequence Identity Sequence Similarity
Homo sapiensHumanNP_659457514100%100%
Pan troglodytesChimpanzeeXP_523923.351499%99%
Callithrix jacchus MarmosetXP_002757278.151492%95%
Ailuropoda melanoleuca PandaXP_002939158.151483%91%
Canis familiaris DogXP_547689.351482%91%
Bos taurus CowXP_002697813.151481%91%
Loxodonata africana ElephantXP_003406348.151480%91%
Rattus norvegicus RatXP_001053914.251471%87%
Mus musculus MouseNP_083224.251470%87%
Ornithorhynchus anatinus PlatypusXP_001509001.246549%72%
Monodelphis domestica OpossumXP_001372850.250747%70%
Xenopus tropicalis FrogNP_001120281.151639%65%
Anolis carolinensis LizardXP_003227331.151437%62%
Nematostella vectensis Sea anemoneXP_001628275.144036%58%
Branchiostoma floridae LanceletXP_002609924.152835%61%
Trichoplax adhaerens TrichoplaxXP_002111027.151433%60%
Danio rerio Zebra fishNP_001038595.251932%58%
Amphimedon queenslandica SpongeXP_003389146.151331%60%

Gene neighborhood

The below image from NCBI shows the gene neighborhood of CCDC11 on chromosome 18. CCDC11 has methyl-CPG binding domain protein 1, MBD1, upstream and myosin VB3, MYO5B, downstream. All CCDC11, MBD1 and MYO5B are oriented negatively. Note the close proximity between MBD1 and CCDC11.

Predicted Post-Translational Modification

Tools on the ExPASy Proteomics site[3] predict the following post-translational modifications:

Tool Predicted Modification Homo sapiens Mus musculus Bos taurus
YinOYang[4]O-β-GlcNAcT239, S510T239T239, S509, T510
NetPhos[5]phosphorylationT8, T17, S43, S53, S56, S57, Y112, T134, S170, S240, S425, S461T17, S43, S53, S56, S107, Y112, S114, S170, T284, S287, S492T17, S56, T64, S107, T112, T122, T325, S442, S482, S507

One tool on the ExPASy, iPSORT, showed no signal peptide;however, it indicated CCDC11 to be mitochondrial. Another toold on the ExPASy, SOSUI, indicated the protein to be a soluble protein.

References

  1. "coiled-coil domain containing 11". Retrieved 25 Feb 2012.
  2. 1 2 3 4 "GeneCards". Retrieved 25 Feb 2012.
  3. "ExPASy Proteomics tools". Retrieved 15 Apr 2012.
  4. "YinOYang". Retrieved 15 Apr 2012.
  5. "NetPhos". Retrieved 15 Apr 2012.
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