CCDC85B

Coiled-coil domain containing 85B
Identifiers
Symbols	CCDC85B ; DIPA
External IDs	OMIM: 605360 MGI: 2147607 HomoloGene: 4989 GeneCards: CCDC85B Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • cytoplasm • centrosome Biological process • transcription, DNA-templated • cell differentiation • negative regulation of cell growth • negative regulation of fat cell differentiation • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11007	240514
Ensembl	ENSG00000175602	ENSMUSG00000095098
UniProt	Q15834	Q6PDY0
RefSeq (mRNA)	NM_006848	NM_001243307
RefSeq (protein)	NP_006839	NP_001230236
Location (UCSC)	Chr 11: 65.89 – 65.89 Mb	Chr 19: 5.46 – 5.46 Mb
PubMed search

Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the CCDC85B gene.^[1][2][3]

Function

Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro.^[3]

Interactions

CCDC85B has been shown to interact with:

• C19orf25,^[4]
• KIAA1267,^[4]
• Keratin 17,^[4] and
• Protein kinase N1.^[4]

References

1. Brazas R, Ganem D (Oct 1996). "A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution". Science 274 (5284): 90–4. doi:10.1126/science.274.5284.90. PMID 8810253.
2. Bezy O, Elabd C, Cochet O, Petersen RK, Kristiansen K, Dani C, Ailhaud G, Amri EZ (Mar 2005). "Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation". The Journal of Biological Chemistry 280 (12): 11432–8. doi:10.1074/jbc.M411741200. PMID 15644333.
3. "Entrez Gene: CCDC85B coiled-coil domain containing 85B".
4. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Robertson HD (Oct 1996). "How did replicating and coding RNAs first get together?". Science 274 (5284): 66–7. doi:10.1126/science.274.5284.66. PMID 8848724.
• Long M, de Souza SJ, Gilbert W (May 1997). "Delta-interacting protein A and the origin of hepatitis delta antigen". Science 276 (5313): 824–5. doi:10.1126/science.276.5313.824. PMID 9115212.
• Schumacher B, Schertel C, Wittenburg N, Tuck S, Mitani S, Gartner A, Conradt B, Shaham S (Feb 2005). "C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage". Cell Death and Differentiation 12 (2): 153–61. doi:10.1038/sj.cdd.4401539. PMID 15605074.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Du X, Wang Q, Hirohashi Y, Greene MI (Dec 2006). "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription". Experimental and Molecular Pathology 81 (3): 184–90. doi:10.1016/j.yexmp.2006.07.008. PMID 17014843.