CCNC (gene)

Cyclin C
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3RGF​, 4F6S​, 4F6U​, 4F6W​, 4F70​, 4F7J​, 4F7L​, 4F7N​, 4F7S​, 4G6L​
Identifiers
Symbols	CCNC ; CycC
External IDs	OMIM: 123838 MGI: 1858199 HomoloGene: 3803 GeneCards: CCNC Gene
Gene ontology Molecular function • protein binding • protein kinase binding • ubiquitin protein ligase activity Cellular component • ubiquitin ligase complex • nucleoplasm • mediator complex Biological process • regulation of cyclin-dependent protein serine/threonine kinase activity • transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • transforming growth factor beta receptor signaling pathway • Notch signaling pathway • gene expression • protein ubiquitination • positive regulation of transcription from RNA polymerase II promoter • negative regulation of triglyceride metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	892	51813
Ensembl	ENSG00000112237	ENSMUSG00000028252
UniProt	P24863	Q62447
RefSeq (mRNA)	NM_001013399	NM_001122982
RefSeq (protein)	NP_001013417	NP_001116454
Location (UCSC)	Chr 6: 99.54 – 99.57 Mb	Chr 4: 21.73 – 21.76 Mb
PubMed search

Cyclin-C is a protein that in humans is encoded by the CCNC gene.^[1][2]

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.^[2]

Interactions

CCNC (gene) has been shown to interact with Estrogen receptor alpha^[3] and Cyclin-dependent kinase 8.^{[4][5][6][3][7]}

References

1. Lew DJ, Dulic V, Reed SI (Oct 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066.
2. "Entrez Gene: CCNC cyclin C".
3. Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.
4. Zhang, Y; Iratni R; Erdjument-Bromage H; Tempst P; Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell (UNITED STATES) 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. ISSN 0092-8674. PMID 9150135.
5. Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (Sep 1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. (UNITED STATES) 18 (9): 5355–63. ISSN 0270-7306. PMC 109120. PMID 9710619.
6. Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. (United States) 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138.
7. Tassan, J P; Jaquenoud M; Léopold P; Schultz S J; Nigg E A (Sep 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (19): 8871–5. doi:10.1073/pnas.92.19.8871. ISSN 0027-8424. PMC 41069. PMID 7568034.

Further reading

• Nozawa T, Hatano M, Yamamoto H, Kwan T (1976). "Magnetic circular dichroism on the reversible oxygenation of dimethylmesoporphyrin-IX-atopyridinecobalt (II)". Bioinorganic chemistry 5 (3): 267–73. doi:10.1016/S0006-3061(00)82025-6. PMID 1260071.
• Tassan JP, Jaquenoud M, Léopold P; et al. (1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. doi:10.1073/pnas.92.19.8871. PMC 41069. PMID 7568034.
• Demetrick DJ, Matsumoto S, Hannon GJ; et al. (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet. Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.
• Yoshizumi M, Lee WS, Hsieh CM; et al. (1995). "Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts". J. Clin. Invest. 95 (5): 2275–80. doi:10.1172/JCI117918. PMC 295840. PMID 7738192.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Rickert P, Seghezzi W, Shanahan F; et al. (1996). "Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II". Oncogene 12 (12): 2631–40. PMID 8700522.
• Li H, Lahti JM, Valentine M; et al. (1997). "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors". Genomics 32 (2): 253–9. doi:10.1006/geno.1996.0112. PMID 8833152.
• Cujec TP, Cho H, Maldonado E; et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028. PMID 9121429.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Neish AS, Anderson SF, Schlegel BP; et al. (1998). "Factors associated with the mammalian RNA polymerase II holoenzyme". Nucleic Acids Res. 26 (3): 847–53. doi:10.1093/nar/26.3.847. PMC 147327. PMID 9443979.
• Cho H, Orphanides G, Sun X; et al. (1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. 18 (9): 5355–63. PMC 109120. PMID 9710619.
• Sun X, Zhang Y, Cho H; et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell 2 (2): 213–22. doi:10.1016/S1097-2765(00)80131-8. PMID 9734358.
• Gu W, Malik S, Ito M; et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
• Ito M, Yuan CX, Malik S; et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
• Rachez C, Lemon BD, Suldan Z; et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.
• Wang G, Cantin GT, Stevens JL, Berk AJ (2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. PMC 87123. PMID 11416138.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sato S, Tomomori-Sato C, Banks CA; et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
• Ueberham U, Hessel A, Arendt T (2003). "Cyclin C expression is involved in the pathogenesis of Alzheimer's disease". Neurobiol. Aging 24 (3): 427–35. doi:10.1016/S0197-4580(02)00132-X. PMID 12600719.