CCNDBP1

Cyclin D-type binding-protein 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3AY5​
Identifiers
Symbols	CCNDBP1 ; DIP1; GCIP; HHM
External IDs	OMIM: 607089 MGI: 109595 HomoloGene: 7826 GeneCards: CCNDBP1 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm Biological process • cell cycle • regulation of cell cycle Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23582	17151
Ensembl	ENSG00000166946	ENSMUSG00000023572
UniProt	O95273	Q3TVC7
RefSeq (mRNA)	NM_012142	NM_010761
RefSeq (protein)	NP_036274	NP_034891
Location (UCSC)	Chr 15: 43.19 – 43.2 Mb	Chr 2: 121.01 – 121.02 Mb
PubMed search

Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1 gene.^[1][2]

This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.^[2]

Interactions

CCNDBP1 has been shown to interact with GRAP2^[3] and Cyclin D1.^[1]

References

1. Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Aug 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J Biol Chem 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID 10801854.
2. "Entrez Gene: CCNDBP1 cyclin D-type binding-protein 1".
3. Xia, C; Bao Z; Tabassam F; Ma W; Qiu M; Hua S; Liu M (Jul 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J. Biol. Chem. (UNITED STATES) 275 (27): 20942–8. doi:10.1074/jbc.M002598200. ISSN 0021-9258. PMID 10801854.

Further reading

• Ma W, Xia X, Stafford LJ; et al. (2006). "Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis.". Oncogene 25 (30): 4207–16. doi:10.1038/sj.onc.1209450. PMID 16501603.
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chang MS, Chen CY, Yeh HI; et al. (2003). "Cloning, expression, and genomic organization of mouse mp29 gene". Biochem. Biophys. Res. Commun. 299 (2): 241–6. doi:10.1016/S0006-291X(02)02605-0. PMID 12437976.
• Dgany O, Avidan N, Delaunay J; et al. (2003). "Congenital Dyserythropoietic Anemia Type I Is Caused by Mutations in Codanin-1". Am. J. Hum. Genet. 71 (6): 1467–74. doi:10.1086/344781. PMC 378595. PMID 12434312.
• Terai S, Aoki H, Ashida K, Thorgeirsson SS (2000). "Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression". Hepatology 32 (2): 357–66. doi:10.1053/jhep.2000.9092. PMID 10915743.
• Yamada S, Iida T, Tabata T; et al. (2000). "Alcoholic fatty liver differentially induces a neutrophil-chemokine and hepatic necrosis after ischemia-reperfusion in rat". Hepatology 32 (2): 278–88. doi:10.1053/jhep.2000.9604. PMID 10915734.
• Yao Y, Doki Y, Jiang W; et al. (2000). "Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins". Exp. Cell Res. 257 (1): 22–32. doi:10.1006/excr.2000.4884. PMID 10854051.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.