CCNF

CCNF may also mean Canonical conjunctive normal form in Boolean algebra.

Cyclin F
Identifiers
Symbols	CCNF ; FBX1; FBXO1
External IDs	OMIM: 600227 MGI: 102551 HomoloGene: 1335 GeneCards: CCNF Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • centriole • SCF ubiquitin ligase complex Biological process • re-entry into mitotic cell cycle • placenta development • mitotic nuclear division • negative regulation of centrosome duplication • protein ubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	899	12449
Ensembl	ENSG00000162063	ENSMUSG00000072082
UniProt	P41002	P51944
RefSeq (mRNA)	NM_001761	NM_007634
RefSeq (protein)	NP_001752	NP_031660
Location (UCSC)	Chr 16: 2.43 – 2.46 Mb	Chr 17: 24.22 – 24.25 Mb
PubMed search

G2/mitotic-specific cyclin-F is a protein that in humans is encoded by the CCNF gene.^[1][2]

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.^[2]

References

1. Kraus B, Pohlschmidt M, Leung AL, Germino GG, Snarey A, Schneider MC, Reeders ST, Frischauf AM (Apr 1995). "A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1)". Genomics 24 (1): 27–33. doi:10.1006/geno.1994.1578. PMID 7896286.
2. "Entrez Gene: CCNF cyclin F".

Further reading

• Nehls M, Lüno K, Schorpp M; et al. (1995). "YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11.". Mamm. Genome 6 (5): 321–31. doi:10.1007/BF00364794. PMID 7626882.
• Bai C, Richman R, Elledge SJ (1995). "Human cyclin F". EMBO J. 13 (24): 6087–98. PMC 395587. PMID 7813445.
• Bai C, Sen P, Hofmann K; et al. (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box". Cell 86 (2): 263–74. doi:10.1016/S0092-8674(00)80098-7. PMID 8706131.
• Kong M, Barnes EA, Ollendorff V, Donoghue DJ (2000). "Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin–cyclin interaction". EMBO J. 19 (6): 1378–88. doi:10.1093/emboj/19.6.1378. PMC 305678. PMID 10716937.
• Fung TK, Siu WY, Yam CH; et al. (2002). "Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins". J. Biol. Chem. 277 (38): 35140–9. doi:10.1074/jbc.M205503200. PMID 12122006.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.