CCNL1

Cyclin L1
Identifiers
Symbols	CCNL1 ; ANIA6A; BM-001; PRO1073; ania-6a
External IDs	OMIM: 613384 MGI: 1922664 HomoloGene: 10541 GeneCards: CCNL1 Gene
Gene ontology Molecular function • protein binding • protein kinase binding Cellular component • nucleus • nuclear speck Biological process • regulation of cyclin-dependent protein serine/threonine kinase activity • transcription, DNA-templated • regulation of transcription, DNA-templated • RNA processing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57018	56706
Ensembl	ENSG00000163660	ENSMUSG00000027829
UniProt	Q9UK58	Q52KE7
RefSeq (mRNA)	NM_001308185	NM_001025442
RefSeq (protein)	NP_001295114	NP_064321
Location (UCSC)	Chr 3: 157.15 – 157.16 Mb	Chr 3: 65.95 – 65.96 Mb
PubMed search

Cyclin-L1 is a protein that in humans is encoded by the CCNL1 gene.^[1][2]

References

1. Dickinson LA, Edgar AJ, Ehley J, Gottesfeld JM (Jul 2002). "Cyclin L is an RS domain protein involved in pre-mRNA splicing". J Biol Chem 277 (28): 25465–73. doi:10.1074/jbc.M202266200. PMID 11980906.
2. "Entrez Gene: CCNL1 cyclin L1".

Further reading

• Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Berke JD, Sgambato V, Zhu PP; et al. (2001). "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin". Neuron 32 (2): 277–87. doi:10.1016/S0896-6273(01)00465-2. PMID 11683997.
• Redon R, Hussenet T, Bour G; et al. (2002). "Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer". Cancer Res. 62 (21): 6211–7. PMID 12414649.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• de Graaf K, Hekerman P, Spelten O; et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sticht C, Hofele C, Flechtenmacher C; et al. (2005). "Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC)". Br. J. Cancer 92 (4): 770–4. doi:10.1038/sj.bjc.6602400. PMC 2361871. PMID 15700036.
• Muller D, Millon R, Théobald S; et al. (2006). "Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma". Br. J. Cancer 94 (7): 1041–4. doi:10.1038/sj.bjc.6603036. PMC 2361229. PMID 16598186.