CD2BP2

CD2 (cytoplasmic tail) binding protein 2
PDB rendering based on 1gyf.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1GYF​, 1L2Z​, 1SYX​, 4BWS​
Identifiers
Symbols	CD2BP2 ; FWP010; LIN1; PPP1R59; Snu40; U5-52K
External IDs	OMIM: 604470 MGI: 1917483 HomoloGene: 4455 GeneCards: CD2BP2 Gene
Gene ontology Molecular function • protein binding • ribonucleoprotein complex binding Cellular component • nucleus • nucleoplasm • U5 snRNP • cytoplasm • nuclear speck • U4/U6 x U5 tri-snRNP complex Biological process • spliceosomal tri-snRNP complex assembly • mRNA splicing, via spliceosome • RNA splicing • gene expression • negative regulation of phosphatase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10421	70233
Ensembl	ENSG00000169217	ENSMUSG00000042502
UniProt	O95400	Q9CWK3
RefSeq (mRNA)	NM_001243646	NM_001285905
RefSeq (protein)	NP_001230575	NP_001272834
Location (UCSC)	Chr 16: 30.35 – 30.36 Mb	Chr 7: 127.19 – 127.2 Mb
PubMed search

CD2 antigen cytoplasmic tail-binding protein 2 is a protein that in humans is encoded by the CD2BP2 gene.^[1][2]

Interactions

CD2BP2 has been shown to interact with CD2.^[1]

References

1. Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (Jan 1999). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc Natl Acad Sci U S A 95 (25): 14897–902. doi:10.1073/pnas.95.25.14897. PMC 24547. PMID 9843987.
2. "Entrez Gene: CD2BP2 CD2 (cytoplasmic tail) binding protein 2".

Further reading

• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Laggerbauer B, Liu S, Makarov E; et al. (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.". RNA 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
• Cohavy O, Zhou J, Ware CF, Targan SR (2005). "LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling.". J. Immunol. 174 (2): 646–53. doi:10.4049/jimmunol.174.2.646. PMID 15634882.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kofler M, Heuer K, Zech T, Freund C (2004). "Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2.". J. Biol. Chem. 279 (27): 28292–7. doi:10.1074/jbc.M402008200. PMID 15105431.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Freund C, Kühne R, Yang H; et al. (2003). "Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules.". EMBO J. 21 (22): 5985–95. doi:10.1093/emboj/cdf602. PMC 137194. PMID 12426371.
• Hirosawa M, Nagase T, Ishikawa K; et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Freund C, Dötsch V, Nishizawa K; et al. (1999). "The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences.". Nat. Struct. Biol. 6 (7): 656–60. doi:10.1038/10712. PMID 10404223.