CD300LF

CD300 molecule-like family member f
PDB rendering based on 2nms.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2NMS​
Identifiers
Symbols	CD300LF ; CD300f; CLM-1; CLM1; IREM-1; IREM1; IgSF13; LMIR3; NKIR
External IDs	OMIM: 609807 MGI: 2442359 HomoloGene: 51396 GeneCards: CD300LF Gene
Gene ontology Molecular function • receptor activity Cellular component • plasma membrane • integral component of membrane Biological process • immune system process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	146722	246746
Ensembl	ENSG00000186074	ENSMUSG00000047798
UniProt	Q8TDQ1	Q6SJQ7
RefSeq (mRNA)	NM_001289082	NM_001169153
RefSeq (protein)	NP_001276011	NP_001162624
Location (UCSC)	Chr 17: 74.69 – 74.71 Mb	Chr 11: 115.12 – 115.13 Mb
PubMed search

CMRF35-like molecule 1 is a protein that in humans is encoded by the CD300LF gene.^[1][2]

CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6; MIM 176883) or SHIP (INPP5D; MIM 601582) (Sui et al., 2004; Alvarez-Errico et al., 2004).[supplied by OMIM]^[2]

References

1. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
2. "Entrez Gene: CD300LF CD300 molecule-like family member f".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chung DH, Humphrey MB, Nakamura MC, et al. (2004). "CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation". J. Immunol. 171 (12): 6541–8. doi:10.4049/jimmunol.171.12.6541. PMID 14662855.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Sui L, Li N, Liu Q, et al. (2004). "IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes". Biochem. Biophys. Res. Commun. 319 (3): 920–8. doi:10.1016/j.bbrc.2004.05.065. PMID 15184070.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Alvarez-Errico D, Aguilar H, Kitzig F, et al. (2005). "IREM-1 is a novel inhibitory receptor expressed by myeloid cells". Eur. J. Immunol. 34 (12): 3690–701. doi:10.1002/eji.200425433. PMID 15549731.
• Alvarez-Errico D, Sayós J, López-Botet M (2007). "The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase". J. Immunol. 178 (2): 808–16. doi:10.4049/jimmunol.178.2.808. PMID 17202342.