CDC23

Cell division cycle 23
Identifiers
Symbols	CDC23 ; ANAPC8; APC8; CUT23
External IDs	OMIM: 603462 MGI: 1098815 HomoloGene: 3426 GeneCards: CDC23 Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding Cellular component • intracellular • nucleoplasm • anaphase-promoting complex • cytosol Biological process • mitotic cell cycle • ubiquitin-dependent protein catabolic process • mitotic nuclear division • mitotic metaphase plate congression • metaphase/anaphase transition of mitotic cell cycle • mitotic spindle assembly checkpoint • regulation of exit from mitosis • regulation of mitotic metaphase/anaphase transition • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • cell division • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • protein K11-linked ubiquitination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8697	52563
Ensembl	ENSG00000094880	ENSMUSG00000024370
UniProt	Q9UJX2	Q8BGZ4
RefSeq (mRNA)	NM_004661	NM_178347
RefSeq (protein)	NP_004652	NP_848124
Location (UCSC)	Chr 5: 138.19 – 138.21 Mb	Chr 18: 34.63 – 34.65 Mb
PubMed search

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.^[1]

Function

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.^[1]

Interactions

CDC23 has been shown to interact with CDC27.^[2][3]

References

1. "Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)".
2. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
3. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC: 16806. PMID 10922056.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (Feb 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science 279 (5354): 1219–22. doi:10.1126/science.279.5354.1219. PMID 9469815.
• Zhao N, Lai F, Fernald AA, Eisenbart JD, Espinosa R, Wang PW, Le Beau MM (Oct 1998). "Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias". Genomics 53 (2): 184–90. doi:10.1006/geno.1998.5473. PMID 9790767.
• Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM (May 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". The Journal of Biological Chemistry 274 (20): 14500–7. doi:10.1074/jbc.274.20.14500. PMID 10318877.
• Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM (Sep 1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proceedings of the National Academy of Sciences of the United States of America 96 (20): 11317–22. doi:10.1073/pnas.96.20.11317. PMC: 18031. PMID 10500174.
• Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC: 16806. PMID 10922056.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC: 1083732. PMID 11256614. Check date values in: |year= / |date= mismatch (help)
• Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893. Check date values in: |year= / |date= mismatch (help)
• Wang Q, Moyret-Lalle C, Couzon F, Surbiguet-Clippe C, Saurin JC, Lorca T, Navarro C, Puisieux A (Mar 2003). "Alterations of anaphase-promoting complex genes in human colon cancer cells". Oncogene 22 (10): 1486–90. doi:10.1038/sj.onc.1206224. PMID 12629511.
• Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. Check date values in: |year= / |date= mismatch (help)
• Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM (Dec 2003). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". The EMBO Journal 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC: 291822. PMID 14657031. Check date values in: |year= / |date= mismatch (help)
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC: 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. Check date values in: |year= / |date= mismatch (help)
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC: 1459365. PMID 16565220.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.