CDCA5

Cell division cycle associated 5
Identifiers
Symbols	CDCA5 ; SORORIN
External IDs	OMIM: 609374 MGI: 1915099 HomoloGene: 49860 GeneCards: CDCA5 Gene
Gene ontology Molecular function • chromatin binding • protein binding Cellular component • chromosome, centromeric region • nuclear chromatin • nucleus • nucleoplasm • chromosome • cytoplasm • cytosol • plasma membrane • cohesin complex Biological process • G1/S transition of mitotic cell cycle • mitotic cell cycle • double-strand break repair • mitotic sister chromatid cohesion • mitotic nuclear division • mitotic chromosome condensation • mitotic metaphase plate congression • positive regulation of exit from mitosis • cell division • regulation of cohesin localization to chromatin • positive regulation of cell cycle phase transition Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	113130	67849
Ensembl	ENSG00000146670	ENSMUSG00000024791
UniProt	Q96FF9	Q9CPY3
RefSeq (mRNA)	NM_080668	NM_026410
RefSeq (protein)	NP_542399	NP_080686
Location (UCSC)	Chr 11: 65.07 – 65.08 Mb	Chr 19: 6.08 – 6.09 Mb
PubMed search

Sororin is a protein that in humans is encoded by the CDCA5 gene.^[1][2][3]

Function

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. ^[4]

Clinical Significance

Transactivation of Sororin and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation. ^[5]

References

1. Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
2. Rankin S, Ayad NG, Kirschner MW (Apr 2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol Cell 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.
3. "Entrez Gene: CDCA5 cell division cycle associated 5".
4. Schmitz, J.; Watrin, E.; Lénárt, P.; Mechtler, K.; Peters, JM. (Apr 2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.". Curr Biol 17 (7): 630–6. doi:10.1016/j.cub.2007.02.029. PMID 17349791.
5. Nguyen, MH.; Koinuma, J.; Ueda, K.; Ito, T.; Tsuchiya, E.; Nakamura, Y.; Daigo, Y. (Jul 2010). "Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis.". Cancer Res 70 (13): 5337–47. doi:10.1158/0008-5472.CAN-09-4372. PMID 20551060.

Further reading

• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Schmitz J, Watrin E, Lénárt P; et al. (2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.". Curr. Biol. 17 (7): 630–6. doi:10.1016/j.cub.2007.02.029. PMID 17349791.
• Díaz-Martínez LA, Giménez-Abián JF, Clarke DJ (2007). "Regulation of centromeric cohesion by sororin independently of the APC/C.". Cell Cycle 6 (6): 714–24. doi:10.4161/cc.6.6.3935. PMID 17361102.