CDCA8

Cell division cycle associated 8

Rendering based on PDB 2KDD​.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CDCA8 ; BOR; BOREALIN; DasraB; MESRGP
External IDs OMIM: 609977 MGI: 1196274 HomoloGene: 23075 GeneCards: CDCA8 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 55143 52276
Ensembl ENSG00000134690 ENSMUSG00000028873
UniProt Q53HL2 Q8BHX3
RefSeq (mRNA) NM_001256875 NM_026560
RefSeq (protein) NP_001243804 NP_080836
Location (UCSC) Chr 1:
37.69 – 37.71 Mb		 Chr 4:
124.92 – 124.94 Mb
PubMed search

Borealin is a protein that in humans is encoded by the CDCA8 gene.[1][2][3]

Function

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.[3][4]

Interactions

CDCA8 has been shown to interact with INCENP,[4] Survivin[2][4] and Aurora B kinase.[2][4]

References

  1. ↑ Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
  2. 1 2 3 Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell 118 (2): 187–202. doi:10.1016/j.cell.2004.06.026. PMID 15260989.
  3. 1 2 "Entrez Gene: CDCA8 cell division cycle associated 8".
  4. 1 2 3 4 Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC: 2172304. PMID 15249581.

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Sauer G, Körner R, Hanisch A, Ries A, Nigg EA, Silljé HH (Jan 2005). "Proteome analysis of the human mitotic spindle". Molecular & Cellular Proteomics 4 (1): 35–43. doi:10.1074/mcp.M400158-MCP200. PMID 15561729. 
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
  • Vader G, Kauw JJ, Medema RH, Lens SM (Jan 2006). "Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody". EMBO Reports 7 (1): 85–92. doi:10.1038/sj.embor.7400562. PMC: 1369225. PMID 16239925. 
  • Noton EA, Colnaghi R, Tate S, Starck C, Carvalho A, Ko Ferrigno P, Wheatley SP (Jan 2006). "Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis". The Journal of Biological Chemistry 281 (2): 1286–95. doi:10.1074/jbc.M508773200. PMID 16291752. 
  • Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM (Apr 2006). "Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer". Experimental Cell Research 312 (7): 962–73. doi:10.1016/j.yexcr.2005.12.015. PMID 16427043. 
  • Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH (Apr 2006). "Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres". Molecular Biology of the Cell 17 (4): 1897–909. doi:10.1091/mbc.E05-08-0727. PMC: 1415303. PMID 16436504. 
  • Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G (Aug 2006). "Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown". Oncogene 25 (35): 4867–79. doi:10.1038/sj.onc.1209499. PMID 16547492. 
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC: 1459365. PMID 16565220. 
  • Klein UR, Nigg EA, Gruneberg U (Jun 2006). "Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP". Molecular Biology of the Cell 17 (6): 2547–58. doi:10.1091/mbc.E05-12-1133. PMC: 1474794. PMID 16571674. 
  • Kaur H, Stiff AC, Date DA, Taylor WR (2007). "Analysis of mitotic phosphorylation of borealin". BMC Cell Biology 8: 5. doi:10.1186/1471-2121-8-5. PMC: 1794407. PMID 17241471. 
  • Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y (May 2007). "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis". Cancer Research 67 (9): 4113–22. doi:10.1158/0008-5472.CAN-06-4705. PMID 17483322. 


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