CDK5R2

Cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Identifiers
Symbols	CDK5R2 ; NCK5AI; P39; p39nck5ai
External IDs	OMIM: 603764 MGI: 1330828 HomoloGene: 2924 GeneCards: CDK5R2 Gene
Gene ontology Molecular function • lipid binding • cyclin-dependent protein kinase 5 activator activity Cellular component • cytoplasm • plasma membrane • cyclin-dependent protein kinase 5 holoenzyme complex Biological process • regulation of cyclin-dependent protein serine/threonine kinase activity • neuron migration • cerebellum development • superior olivary nucleus maturation • hippocampus development • layer formation in cerebral cortex • positive regulation of calcium ion-dependent exocytosis • positive regulation of protein serine/threonine kinase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8941	12570
Ensembl	ENSG00000171450	ENSMUSG00000090071
UniProt	Q13319	O35926
RefSeq (mRNA)	NM_003936	NM_009872
RefSeq (protein)	NP_003927	NP_034002
Location (UCSC)	Chr 2: 218.96 – 218.96 Mb	Chr 1: 74.85 – 74.86 Mb
PubMed search

Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene.^[1][2]

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins.^[2]

Interactions

CDK5R2 has been shown to interact with Actinin, alpha 1.^[3]

References

1. Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH (Dec 1995). "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator". J Biol Chem 270 (45): 26897–903. doi:10.1074/jbc.270.45.26897. PMID 7592934.
2. "Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)".
3. Dhavan, Rani; Greer Paul L; Morabito Maria A; Orlando Lianna R; Tsai Li-Huei (Sep 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". J. Neurosci. (United States) 22 (18): 7879–91. PMID 12223541.

Further reading

• Humbert S, Dhavan R, Tsai L (2000). "p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton.". J. Cell. Sci. 113 (6): 975–83. PMID 10683146.
• Humbert S, Lanier LM, Tsai LH (2001). "Synaptic localization of p39, a neuronal activator of cdk5.". NeuroReport 11 (10): 2213–6. doi:10.1097/00001756-200007140-00030. PMID 10923673.
• Muravenko OV, Gizatullin RZ, Protopopov AI; et al. (2000). "Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization.". Cytogenet. Cell Genet. 89 (3-4): 160–1. doi:10.1159/000015602. PMID 10965112.
• Agarwal-Mawal A, Paudel HK (2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2.". J. Biol. Chem. 276 (26): 23712–8. doi:10.1074/jbc.M010002200. PMID 11320080.
• Patzke H, Tsai LH (2002). "Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29.". J. Biol. Chem. 277 (10): 8054–60. doi:10.1074/jbc.M109645200. PMID 11784720.
• Dhavan R, Greer PL, Morabito MA; et al. (2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner.". J. Neurosci. 22 (18): 7879–91. PMID 12223541.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sakashita G, Shima H, Komatsu M; et al. (2004). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells.". J. Biochem. 133 (2): 165–71. doi:10.1093/jb/mvg020. PMID 12761178.
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Rademakers R, Sleegers K, Theuns J; et al. (2005). "Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.". Neurobiol. Aging 26 (8): 1145–51. doi:10.1016/j.neurobiolaging.2004.10.003. PMID 15917097.