CDK5RAP1

CDK5 regulatory subunit associated protein 1
Identifiers
Symbols	CDK5RAP1 ; C20orf34; C42; CGI-05; HSPC167
External IDs	OMIM: 608200 MGI: 1914221 HomoloGene: 9502 GeneCards: CDK5RAP1 Gene
Gene ontology Molecular function • protein kinase regulator activity • protein kinase binding • protein complex binding • methylthiotransferase activity • metal ion binding • 4 iron, 4 sulfur cluster binding Cellular component • cellular_component • cytoplasm Biological process • brain development • tRNA methylthiolation • regulation of neuron differentiation • negative regulation of cyclin-dependent protein serine/threonine kinase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51654	66971
Ensembl	ENSG00000101391	ENSMUSG00000027487
UniProt	Q96SZ6	Q8BTW8
RefSeq (mRNA)	NM_001278167	NM_025876
RefSeq (protein)	NP_001265096	NP_080152
Location (UCSC)	Chr 20: 33.36 – 33.4 Mb	Chr 2: 154.34 – 154.37 Mb
PubMed search

CDK5 regulatory subunit-associated protein 1 is a protein that in humans is encoded by the CDK5RAP1 gene.^[1][2][3][4]

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. Multiple transcript variants exist for this gene, but the full-length natures of only two have been determined.^[4]

References

1. Ching YP, Qi Z, Wang JH (Apr 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.
2. Ching YP, Pang AS, Lam WH, Qi RZ, Wang JH (Apr 2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor". J Biol Chem 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.
3. Zou X, Ji C, Jin F, Liu J, Wu M, Zheng H, Wang Y, Li X, Xu J, Gu S, Xie Y, Mao Y (Aug 2004). "Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1". Genes Genet Syst 79 (3): 177–82. doi:10.1266/ggs.79.177. PMID 15329498.
4. "Entrez Gene: CDK5RAP1 CDK5 regulatory subunit associated protein 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lai CH, Chou CY, Ch'ang LY; et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Wang X, Ching YP, Lam WH; et al. (2000). "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.
• Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.