CDK5RAP3

CDK5 regulatory subunit associated protein 3
Identifiers
Symbols	CDK5RAP3 ; C53; HSF-27; IC53; LZAP; MST016; OK/SW-cl.114; PP1553
External IDs	OMIM: 608202 MGI: 1933126 HomoloGene: 12718 GeneCards: CDK5RAP3 Gene
Gene ontology Molecular function • protein binding • protein kinase binding • cyclin binding • ubiquitin-like protein ligase binding • NF-kappaB binding • MDM2/MDM4 family protein binding Cellular component • nucleus • nucleolus • cytoplasm • centrosome • endomembrane system • membrane • protein complex Biological process • regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of protein phosphorylation • mitotic G2 DNA damage checkpoint • brain development • cell proliferation • positive regulation of protein ubiquitination • negative regulation of NF-kappaB transcription factor activity • mitotic G2/M transition checkpoint • regulation of neuron differentiation • positive regulation of transcription from RNA polymerase II promoter • protein ufmylation • negative regulation of protein serine/threonine kinase activity • positive regulation of protein localization to nucleus • positive regulation of signal transduction by p53 class mediator • negative regulation of cellular protein catabolic process • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80279	80280
Ensembl	ENSG00000108465	ENSMUSG00000018669
UniProt	Q96JB5	Q99LM2
RefSeq (mRNA)	NM_001278197	NM_001308183
RefSeq (protein)	NP_001265126	NP_001295112
Location (UCSC)	Chr 17: 47.97 – 47.98 Mb	Chr 11: 96.91 – 96.92 Mb
PubMed search

CDK5 regulatory subunit-associated protein 3 is a protein that in humans is encoded by the CDK5RAP3 gene.^[1][2]

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.^[2]

References

1. Ching YP, Qi Z, Wang JH (Apr 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.
2. "Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang X, Ching YP, Lam WH; et al. (2000). "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.
• Ching YP, Pang AS, Lam WH; et al. (2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor". J. Biol. Chem. 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.
• Chen J, Liu B, Liu Y; et al. (2002). "A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart". Biochem. Biophys. Res. Commun. 294 (1): 161–6. doi:10.1016/S0006-291X(02)00446-1. PMID 12054757.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Xie YH, He XH, Tang YT; et al. (2003). "Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein". Cell Res. 13 (2): 83–91. doi:10.1038/sj.cr.7290153. PMID 12737517.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Cen H, Zheng S, Fang YM; et al. (2004). "Induction of HSF1 expression is associated with sporadic colorectal cancer". World J. Gastroenterol. 10 (21): 3122–6. PMID 15457556.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jiang H, Luo S, Li H (2005). "Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint". J. Biol. Chem. 280 (21): 20651–9. doi:10.1074/jbc.M413431200. PMID 15790566.
• Yin X, Warner DR, Roberts EA; et al. (2005). "Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53". Int. J. Mol. Med. 16 (2): 251–6. doi:10.3892/ijmm.16.2.251. PMID 16012757.
• Wang J, He X, Luo Y, Yarbrough WG (2006). "A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2". Biochem. J. 393 (Pt 2): 489–501. doi:10.1042/BJ20050960. PMC 1360699. PMID 16173922.
• Kim E, Chen F, Wang CC, Harrison LE (2006). "CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation". Int. J. Oncol. 28 (1): 191–4. doi:10.3892/ijo.28.1.191. PMID 16327995.
• Camargo LM, Collura V, Rain JC; et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Stav D, Bar I, Sandbank J (2007). "Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma". Int. J. Biol. Markers 22 (2): 108–13. PMID 17549666.
• Wang J, An H, Mayo MW; et al. (2007). "LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB". Cancer Cell 12 (3): 239–51. doi:10.1016/j.ccr.2007.07.002. PMID 17785205.