CDON

Cell adhesion associated, oncogene regulated
Rendering based on PDB 3D1M​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3D1M​, 3N1F​, 3N1Q​
Identifiers
Symbols	CDON ; CDO; CDON1; HPE11; ORCAM
External IDs	OMIM: 608707 MGI: 1926387 HomoloGene: 22996 GeneCards: CDON Gene
Gene ontology Molecular function • protein binding Cellular component • plasma membrane • cell surface • integral component of membrane • extracellular matrix Biological process • cell fate specification • lens development in camera-type eye • cell adhesion • myoblast fusion • anterior/posterior pattern specification • embryonic body morphogenesis • skeletal muscle satellite cell differentiation • cerebral cortex development • muscle cell differentiation • positive regulation of MAPK cascade • regulation of protein heterodimerization activity • positive regulation of neuron differentiation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of skeletal muscle tissue development • positive regulation of small GTPase mediated signal transduction • positive regulation of muscle cell differentiation • embryonic retina morphogenesis in camera-type eye • positive regulation of neural precursor cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50937	57810
Ensembl	ENSG00000064309	ENSMUSG00000038119
UniProt	Q4KMG0	Q32MD9
RefSeq (mRNA)	NM_001243597	NM_021339
RefSeq (protein)	NP_001230526	NP_067314
Location (UCSC)	Chr 11: 125.96 – 126.06 Mb	Chr 9: 35.42 – 35.51 Mb
PubMed search

Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene.^[1][2]

CDON and BOC (MIM 608708) are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM]^[2]

Interactions

CDON has been shown to interact with CDH1^[3] and BOC.^[4]

References

1. Kang JS, Gao M, Feinleib JL, Cotter PD, Guadagno SN, Krauss RS (Aug 1997). "CDO: An Oncogene-, Serum-, and Anchorage-regulated Member of the Ig/Fibronectin Type III Repeat Family". J Cell Biol 138 (1): 203–13. doi:10.1083/jcb.138.1.203. PMC 2139939. PMID 9214393.
2. "Entrez Gene: CDON Cdon homolog (mouse)".
3. Kang, Jong-Sun; Feinleib Jessica L; Knox Sarah; Ketteringham Michael A; Krauss Robert S (Apr 2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (7): 3989–94. doi:10.1073/pnas.0736565100. ISSN 0027-8424. PMC 153035. PMID 12634428.
4. Kang, Jong-Sun; Mulieri Philip J; Hu Yulan; Taliana Lavinia; Krauss Robert S (Jan 2002). "BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation". EMBO J. (England) 21 (1–2): 114–24. doi:10.1093/emboj/21.1.114. ISSN 0261-4189. PMC 125805. PMID 11782431.

Further reading

• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wegorzewska M, Krauss RS, Kang JS (2003). "Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD". Mol. Carcinog. 37 (1): 1–4. doi:10.1002/mc.10121. PMID 12720294.
• Kang JS, Feinleib JL, Knox S; et al. (2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 3989–94. doi:10.1073/pnas.0736565100. PMC 153035. PMID 12634428.
• Cole F, Krauss RS (2003). "Microform holoprosencephaly in mice that lack the Ig superfamily member Cdon". Curr. Biol. 13 (5): 411–5. doi:10.1016/S0960-9822(03)00088-5. PMID 12620190.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kang JS, Mulieri PJ, Hu Y; et al. (2002). "BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation". EMBO J. 21 (1–2): 114–24. doi:10.1093/emboj/21.1.114. PMC 125805. PMID 11782431.