CELA3A
| Chymotrypsin-like elastase family, member 3A | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | CELA3A ; ELA3; ELA3A | ||||||||||
| External IDs | HomoloGene: 129880 ChEMBL: 2809 GeneCards: CELA3A Gene | ||||||||||
| EC number | 3.4.21.70 | ||||||||||
| |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 10136 | 242711 | |||||||||
| Ensembl | ENSG00000142789 | ENSMUSG00000078520 | |||||||||
| UniProt | P09093 | n/a | |||||||||
| RefSeq (mRNA) | NM_005747 | NM_001126318 | |||||||||
| RefSeq (protein) | NP_005738 | NP_001119790 | |||||||||
| Location (UCSC) |
Chr 1: 22 – 22.01 Mb |
Chr 4: 137.4 – 137.41 Mb | |||||||||
| PubMed search | |||||||||||
Chymotrypsin-like elastase family member 3A is an enzyme that in humans is encoded by the CELA3A gene.[1][2][3]
Function
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1.[3]
References
- ↑ Tani T, Ohsumi J, Mita K, Takiguchi Y (Feb 1988). "Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning". J Biol Chem 263 (3): 1231–9. PMID 2826474.
- ↑ Shirasu Y, Takemura K, Yoshida H, Sato Y, Iijima H, Shimada Y, Mikayama T, Ozawa T, Ikeda N, Ishida A; et al. (Dec 1988). "Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes". J Biochem 104 (2): 259–64. PMID 2460440.
- 1 2 "Entrez Gene: ELA3A elastase 3A, pancreatic".
Further reading
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Shimada S, Yamaguchi K, Takahashi M, Ogawa M (2002). "Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells.". Int. J. Mol. Med. 10 (5): 599–603. doi:10.3892/ijmm.10.5.599. PMID 12373299.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
External links
- CELA3A human gene location in the UCSC Genome Browser.
- CELA3A human gene details in the UCSC Genome Browser.