CENTD2

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Identifiers
Symbols	ARAP1 ; CENTD2
External IDs	OMIM: 606646 MGI: 1916960 HomoloGene: 12326 GeneCards: ARAP1 Gene
Gene ontology Molecular function • GTPase activator activity • protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • type 1 angiotensin receptor binding • metal ion binding Cellular component • Golgi apparatus • trans-Golgi network • cytosol • plasma membrane • cytoplasmic vesicle • Golgi cisterna membrane Biological process • positive regulation of receptor recycling • small GTPase mediated signal transduction • regulation of cell shape • actin filament reorganization involved in cell cycle • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction • regulation of cellular component movement • positive regulation of filopodium assembly • negative regulation of stress fiber assembly Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116985	69710
Ensembl	ENSG00000186635	ENSMUSG00000032812
UniProt	Q96P48	Q4LDD4
RefSeq (mRNA)	NM_001040118	NM_001040111
RefSeq (protein)	NP_001035207	NP_001035200
Location (UCSC)	Chr 11: 72.69 – 72.79 Mb	Chr 7: 101.35 – 101.41 Mb
PubMed search

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.^[1]

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. The RHO-GAP activity may mediate cell rounding and loss of stress fibers. At least three transcript variants encoding different isoforms have been found for this gene, but the full-length natures of all variants have not been determined.^[1]

References

1. "Entrez Gene: CENTD2 centaurin, delta 2".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol. Cell 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
• Miura K, Jacques KM, Stauffer S, et al. (2002). "ARAP1: a point of convergence for Arf and Rho signaling". Mol. Cell 9 (1): 109–19. doi:10.1016/S1097-2765(02)00428-8. PMID 11804590.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". J. Biochem. Mol. Biol. 37 (6): 741–8. PMID 15607035.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.