CENTD3

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KG5​, 2LNW​
Identifiers
Symbols	ARAP3 ; CENTD3; DRAG1
External IDs	OMIM: 606647 MGI: 2147274 HomoloGene: 11199 GeneCards: ARAP3 Gene
Gene ontology Molecular function • GTPase activator activity • protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • phosphatidylinositol-3,4-bisphosphate binding • metal ion binding Cellular component • ruffle • cytoplasm • cytosol • cytoskeleton • plasma membrane • lamellipodium Biological process • cytoskeleton organization • small GTPase mediated signal transduction • regulation of cell shape • vesicle-mediated transport • negative regulation of cell migration • negative regulation of Rac protein signal transduction • negative regulation of Rho protein signal transduction • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64411	106952
Ensembl	ENSG00000120318	ENSMUSG00000024451
UniProt	Q8WWN8	Q8R5G7
RefSeq (mRNA)	NM_022481	NM_001205336
RefSeq (protein)	NP_071926	NP_001192265
Location (UCSC)	Chr 5: 141.65 – 141.68 Mb	Chr 18: 37.97 – 38 Mb
PubMed search

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.^[1][2][3]

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.^[3]

References

1. Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT (Jan 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol Cell 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
2. Santy LC, Casanova JE (May 2002). "GTPase signaling: bridging the GAP between ARF and Rho". Curr Biol 12 (10): R360–2. doi:10.1016/S0960-9822(02)00860-6. PMID 12015138.
3. "Entrez Gene: CENTD3 centaurin, delta 3".

Further reading

• Raaijmakers JH, Deneubourg L, Rehmann H, et al. (2007). "The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner". Cell. Signal. 19 (6): 1249–57. doi:10.1016/j.cellsig.2006.12.015. PMID 17314030.
• Lu Q, Wei W, Kowalski PE, et al. (2005). "EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin". Proc. Natl. Acad. Sci. U.S.A. 101 (49): 17246–51. doi:10.1073/pnas.0407794101. PMC 534609. PMID 15569923.
• I ST, Nie Z, Stewart A, et al. (2005). "ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner". J. Cell. Sci. 117 (Pt 25): 6071–84. doi:10.1242/jcs.01526. PMID 15546919.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Reinhard C, Schweikert M, Wieland FT, Nickel W (2003). "Functional reconstitution of COPI coat assembly and disassembly using chemically defined components". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8253–7. doi:10.1073/pnas.1432391100. PMC 166215. PMID 12832619.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.