CFHR1
| Complement factor H-related 1 | |||||||||||||
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PDB rendering based on 2bzm. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CFHR1 ; CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; H36-1; H36-2; HFL1; HFL2 | ||||||||||||
| External IDs | OMIM: 134371 MGI: 2138169 HomoloGene: 55632 GeneCards: CFHR1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3078 | 50702 | |||||||||||
| Ensembl | ENSG00000244414 | ENSMUSG00000057037 | |||||||||||
| UniProt | Q03591 | Q61406 | |||||||||||
| RefSeq (mRNA) | NM_002113 | NM_015780 | |||||||||||
| RefSeq (protein) | NP_002104 | NP_056595 | |||||||||||
| Location (UCSC) |
Chr 1: 196.82 – 196.83 Mb |
Chr 1: 139.55 – 139.56 Mb | |||||||||||
| PubMed search | |||||||||||||
Complement factor H-related protein 1 is a protein that in humans is encoded by the CFHR1 gene.[1][2][3]
References
- ↑ Skerka C, Horstmann RD, Zipfel PF (Jul 1991). "Molecular cloning of a human serum protein structurally related to complement factor H". J Biol Chem 266 (18): 12015–20. PMID 1711047.
- ↑ Estaller C, Koistinen V, Schwaeble W, Dierich MP, Weiss EH (May 1991). "Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule". J Immunol 146 (9): 3190–6. PMID 1826708.
- ↑ "Entrez Gene: CFHR1 complement factor H-related 1".
Further reading
- Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an expanding family of complement-regulatory proteins?". Immunol. Today 15 (3): 121–6. doi:10.1016/0167-5699(94)90155-4. PMID 8172644.
- Zipfel PF, Jokiranta TS, Hellwage J; et al. (1999). "The factor H protein family.". Immunopharmacology 42 (1-3): 53–60. doi:10.1016/S0162-3109(99)00015-6. PMID 10408366.
- Timmann C, Leippe M, Horstmann RD (1991). "Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement regulatory functions.". J. Immunol. 146 (4): 1265–70. PMID 1825108.
- Park CT, Wright SD (1996). "Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins.". J. Biol. Chem. 271 (30): 18054–60. doi:10.1074/jbc.271.30.18054. PMID 8663389.
- Díaz-Guillén MA, Rodríguez de Córdoba S, Heine-Suñer D (1999). "A radiation hybrid map of complement factor H and factor H-related genes.". Immunogenetics 49 (6): 549–52. doi:10.1007/s002510050534. PMID 10380701.
- Male DA, Ormsby RJ, Ranganathan S; et al. (2000). "Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes.". Mol. Immunol. 37 (1-2): 41–52. doi:10.1016/S0161-5890(00)00024-9. PMID 10781834.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Pérez-Caballero D, García-Laorden I, Cortés G; et al. (2005). "Interaction between complement regulators and Streptococcus pyogenes: binding of C4b-binding protein and factor H/factor H-like protein 1 to M18 strains involves two different cell surface molecules.". J. Immunol. 173 (11): 6899–904. doi:10.4049/jimmunol.173.11.6899. PMID 15557185.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- McDowell JV, Lankford J, Stamm L; et al. (2005). "Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans.". Infect. Immun. 73 (11): 7126–32. doi:10.1128/IAI.73.11.7126-7132.2005. PMC 1273895. PMID 16239506.
- Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Zipfel PF, Edey M, Heinen S; et al. (2007). "Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome.". PLoS Genet. 3 (3): e41. doi:10.1371/journal.pgen.0030041. PMC 1828695. PMID 17367211.
- Haupt K, Kraiczy P, Wallich R; et al. (2007). "Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins.". J. Infect. Dis. 196 (1): 124–33. doi:10.1086/518509. PMID 17538892.
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External links
- GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
- OMIM entries on Atypical Hemolytic-Uremic Syndrome
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